Nampt-IN-19
Nampt-IN-19 is an orally active and non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a human Ki of 5.6 nM. Nampt-IN-19 blocks NAD+ biosynthesis from Nicotinamide (HY-B0150). Nampt-IN-19 acts as an antiproliferative agent in cancer cells. Nampt-IN-19 has preclinical pharmacokinetic properties supporting oral antitumor activity in mouse xenograft models. Nampt-IN-19 can be used for the research of colorectal cancer.
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- CAS No.: 2109805-79-8
- Formule: C25H31N3O3
- Masse moléculaire:421.53
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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Cell Line
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Type | Value | Description | References |
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| PC-3 | IC50 |
24 nM
Compound: 52
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Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 5 days by Cell-titer Glo reagent based assay
Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 5 days by Cell-titer Glo reagent based assay
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[PMID: 28610984] |
Nampt-IN-19 (52) binds to human NAMPT with a Ki of 5.6 nM[1].
Nampt-IN-19 inhibits PC-3 human prostate cancer cell viability with an IC50 of 24 nM[1].
Nampt-IN-19 inhibits CYP3A4 with an IC50 of 16 μM and CYP2C9 with an IC50 of 8.4 μM[1].
Nampt-IN-19 has a scaled unbound intrinsic clearance of <3.4 L/h/kg in rat microsomes[1].
Nampt-IN-19 has a scaled unbound intrinsic clearance of 18 L/h/kg in mouse microsomes[1].
Nampt-IN-19 has a scaled unbound intrinsic clearance of 3.5 L/h/kg in human microsomes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2109805-79-8
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Masse moléculaire 421.53
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Formule C25H31N3O3
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SMILES
O=C(N1CC2=C(C1)C=CC=C2)NC3=CC=C(C4CCN(CC4)C(CC(C)(C)O)=O)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nampt-IN-19 Related Classifications
HY-182567 Related Classifications
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