2247884-06-4
Chemical Structure
NAMPT/IDO1-IN-1
- CAS 番号: 2247884-06-4
- Formula:C23H24BrFN8O3
- Molecular Weight:559.39
IUPAC Name: (Z)-N-(6-((4-(N-(3-bromo-4-fluorophenyl)-N'-hydroxycarbamimidoyl)-1,2,5-oxadiazol-3-yl)amino)hexyl)imidazo[1,2-a]pyridine-6-carboxamide
InChIKey: CGHBNLCYTYSIJV-UHFFFAOYSA-N
SMILES: BrC(C=C1N/C(C2=NON=C2NCCCCCCNC(C3=CN4C(C=C3)=NC=C4)=O)=N\O)=C(C=C1)F
Biological Activity: NAMPT/IDO1-IN-1 is an orally active dual inhibitor of NAMPT and IDO1 with IC50s of 57.7 nM and 233 nM, respectively. NAMPT/IDO1-IN-1 blocks NAD+ biosynthesis, inhibits proliferation and migration of Paclitaxel (HY-B0015)- and FK866 (HY-50876)-resistant NSCLC cell lines (A549/R cells). NAMPT/IDO1-IN-1 has shown antitumor effects in mice and enhanced A549/R cell sensitivity to paclitaxel[1].
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NAMPT/IDO1-IN-1 | NAMPT/IDO1-IN-1 is an orally active dual inhibitor of NAMPT and IDO1 with IC50s of 57.7 nM and 233 nM, respectively. NAMPT/IDO1-IN-1 blocks NAD+ biosynthesis, inhibits proliferation and migration of Paclitaxel (HY-B0015)- and FK866 (HY-50876)-resistant NSCLC cell lines (A549/R cells). NAMPT/IDO1-IN-1 has shown antitumor effects in mice and enhanced A549/R cell sensitivity to paclitaxel. | |||||||||||||||||||||
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