Nampt-IN-20
Nampt-IN-20 is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor with a IC50 of 9.0 nM. Nampt-IN-20 binds to the active site of Nampt, occupies the NAM-binding region and disrupts NAD biosynthesis. Nampt-IN-20 exerts antiproliferative effects in A2780 ovarian cancer cells. Nampt-IN-20 can be used for the research of ovarian cancer.
For research use only. We do not sell to patients.
- CAS No.: 1362150-16-0
- Formula: C21H17N3O3S
- Molecular Weight:391.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Nampt-IN-20 (compound 7) potently inhibits purified Nampt protein with an IC50 of 9.0 nM[1].
Nampt-IN-20 potently inhibits A2780 ovarian cancer cell proliferation with an IC50 of 0.010 μM[1].
Nampt-IN-20 (30 minutes) shows low stability in mouse liver microsomes, with only 1.9% remaining after 30 minutes[1].
Nampt-IN-20 (30 minutes) shows moderate stability in human liver microsomes, with 44% remaining after 30 minutes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1362150-16-0
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Molecular Weight 391.45
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Formula C21H17N3O3S
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SMILES
O=C(NCC1=CC=C(C=C1)S(=O)(=O)C=2C=CC=CC2)C3=CC=4C=NC=CC4N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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