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Results for "

NBS

" in MedChemExpress (MCE) Product Catalog:

6

Inhibitors & Agonists

1

Biochemical Assay Reagents

1

Recombinant Proteins

4

Antibodies

2

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-19959
    Mirin
    5+ Cited Publications

    		 ATM/ATR Apoptosis Cancer
    Mirin is a potent Mre11-Rad50-Nbs1 (MRN) complex inhibitor. Mirin prevents MRN-dependent activation of ATM (IC50=12 μM) without affecting ATM protein kinase activity, and it inhibits Mre11-associated exonuclease activity. Mirin abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells. Mirin prevents ATM activation in response to DNA double-strand breaks (DSBs) and blocks homology-directed repair (HDR) in mammalian cells .
    Mirin
  • HY-117693
    (E/Z)-Mirin
    5+ Cited Publications

    		 ATM/ATR Cancer
    (E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity .
    (E/Z)-Mirin
  • HY-59261
    2-Amino-5-bromopyrazine

    		Biochemical Assay Reagents Others
    2-Amino-5-bromopyrazine is a monobrominated 2-aminopyrazine derivative and functionalized intermediate for the synthesis of nitrogen heterocycles .
    2-Amino-5-bromopyrazine
  • HY-RS09371
    NME1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NME1 Human Pre-designed siRNA Set A contains three designed siRNAs for NME1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NME1 Human Pre-designed siRNA Set A
    NME1 Human Pre-designed siRNA Set A
  • HY-150038
    NOSH-aspirin

    NBS-1120

    		 NF-κB Apoptosis Neurological Disease Cancer
    NOSH-aspirin (NBS-1120) is an orally active hybrid molecule that releases nitric oxide and hydrogen sulfide. NOSH-aspirin inhibits pancreatic cancer cell proliferation and induces apoptosis. NOSH-aspirin inhibits cancer cell growth and suppresses NF-κB and FoxM1 in a mouse model of pancreatic cancer. NOSH-aspirin also alleviates motor deficits and dopaminergic neuron degeneration in a rat model of Parkinson's disease. NOSH-aspirin reduces neuroinflammation caused by microglial and astrocytic activation. NOSH-aspirin can be used in research on cancers such as pancreatic cancer and neurological diseases such as Parkinson's disease .
    NOSH-aspirin
  • HY-RS09057
    NBN Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NBN Human Pre-designed siRNA Set A contains three designed siRNAs for NBN gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NBN Human Pre-designed siRNA Set A
    NBN Human Pre-designed siRNA Set A

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