2. NF-κB Apoptosis
  3. NF-κB Apoptosis
  4. NOSH-aspirin

NOSH-aspirin (NBS-1120) is an orally active hybrid molecule that releases nitric oxide and hydrogen sulfide. NOSH-aspirin inhibits pancreatic cancer cell proliferation and induces apoptosis. NOSH-aspirin inhibits cancer cell growth and suppresses NF-κB and FoxM1 in a mouse model of pancreatic cancer. NOSH-aspirin also alleviates motor deficits and dopaminergic neuron degeneration in a rat model of Parkinson's disease. NOSH-aspirin reduces neuroinflammation caused by microglial and astrocytic activation. NOSH-aspirin can be used in research on cancers such as pancreatic cancer and neurological diseases such as Parkinson's disease.

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NOSH-aspirin

NOSH-aspirin Chemical Structure

CAS No. : 1357362-67-4

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NOSH-aspirin Related Antibodies

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Description

NOSH-aspirin (NBS-1120) is an orally active hybrid molecule that releases nitric oxide and hydrogen sulfide. NOSH-aspirin inhibits pancreatic cancer cell proliferation and induces apoptosis. NOSH-aspirin inhibits cancer cell growth and suppresses NF-κB and FoxM1 in a mouse model of pancreatic cancer. NOSH-aspirin also alleviates motor deficits and dopaminergic neuron degeneration in a rat model of Parkinson's disease. NOSH-aspirin reduces neuroinflammation caused by microglial and astrocytic activation. NOSH-aspirin can be used in research on cancers such as pancreatic cancer and neurological diseases such as Parkinson's disease[1][2][3].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
50 nM
Compound: NOSH-1
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
Cytotoxicity against human A549 cells after 24 hrs by MTT assay
[PMID: 22916316]
BXPC-3 IC50
57 nM
Compound: NOSH-1
Cytotoxicity against human BxPC3 cells expressing COX1 and COX2 after 24 hrs by MTT assay
Cytotoxicity against human BxPC3 cells expressing COX1 and COX2 after 24 hrs by MTT assay
[PMID: 22916316]
HCT-15 IC50
50 nM
Compound: NOSH-1
Cytotoxicity against COX deficient human HCT15 cells after 24 hrs by MTT assay
Cytotoxicity against COX deficient human HCT15 cells after 24 hrs by MTT assay
[PMID: 22916316]
HCT-15 IC50
57 nM
Compound: 1
Cytotoxicity against human HCT15 cells assessed as growth inhibition after 24 hrs by MTT assay
Cytotoxicity against human HCT15 cells assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 26323873]
HT-29 IC50
48 nM
Compound: 1
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 24 hrs by MTT assay
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 24 hrs by MTT assay
[PMID: 26323873]
HT-29 IC50
48 nM
Compound: NOSH-1
Cytotoxicity against human HT-29 cells expressing COX1 and COX2 after 24 hrs by MTT assay
Cytotoxicity against human HT-29 cells expressing COX1 and COX2 after 24 hrs by MTT assay
[PMID: 22916316]
Jurkat IC50
100 nM
Compound: NOSH-1
Cytotoxicity against human Jurkat cells expressing COX1 and COX2 after 24 hrs by MTT assay
Cytotoxicity against human Jurkat cells expressing COX1 and COX2 after 24 hrs by MTT assay
[PMID: 22916316]
LNCaP IC50
88 nM
Compound: NOSH-1
Cytotoxicity against human LNCAP cells after 24 hrs by MTT assay
Cytotoxicity against human LNCAP cells after 24 hrs by MTT assay
[PMID: 22916316]
MCF7 IC50
280 nM
Compound: NOSH-1
Cytotoxicity against human MCF7 cells expressing ER after 24 hrs by MTT assay
Cytotoxicity against human MCF7 cells expressing ER after 24 hrs by MTT assay
[PMID: 22916316]
MDA-MB-231 IC50
100 nM
Compound: NOSH-1
Cytotoxicity against ER deficient human MDA-MB-231 cells after 24 hrs by MTT assay
Cytotoxicity against ER deficient human MDA-MB-231 cells after 24 hrs by MTT assay
[PMID: 22916316]
MIA PaCa-2 IC50
47 nM
Compound: NOSH-1
Cytotoxicity against COX deficient human MIAPaCa2 cells after 24 hrs by MTT assay
Cytotoxicity against COX deficient human MIAPaCa2 cells after 24 hrs by MTT assay
[PMID: 22916316]
SK-BR-3 IC50
75 nM
Compound: NOSH-1
Cytotoxicity against ER deficient human SKBR3 cells after 24 hrs by MTT assay
Cytotoxicity against ER deficient human SKBR3 cells after 24 hrs by MTT assay
[PMID: 22916316]
SW480 IC50
60 nM
Compound: NOSH-1
Cytotoxicity against human SW480 cells expressing COX1 after 24 hrs by MTT assay
Cytotoxicity against human SW480 cells expressing COX1 after 24 hrs by MTT assay
[PMID: 22916316]
Molecular Weight

477.53

Formula

C20H15NO7S3
CAS No.
SMILES

O=C(OC1=CC=C(C(SS2)=CC2=S)C=C1)C3=CC=CC=C3OC(CCCO[N+]([O-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NOSH-aspirin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NOSH-aspirin1357362-67-4NBS-1120NBS1120NBS 1120NF-κBApoptosisNuclear factor-κBNuclear factor-kappaBInhibitorinhibitorinhibit

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