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Cat. No.: HY-150038

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NOSH-aspirin

Name: NOSH-aspirin
Brand: MedChemExpress
SKU: HY-150038
Availability: PreOrder

(Synonyms: NBS-1120)

NOSH-aspirin (NBS-1120) is an orally active hybrid molecule that releases nitric oxide and hydrogen sulfide. NOSH-aspirin inhibits pancreatic cancer cell proliferation and induces apoptosis. NOSH-aspirin inhibits cancer cell growth and suppresses NF-κB and FoxM1 in a mouse model of pancreatic cancer. NOSH-aspirin also alleviates motor deficits and dopaminergic neuron degeneration in a rat model of Parkinson's disease. NOSH-aspirin reduces neuroinflammation caused by microglial and astrocytic activation. NOSH-aspirin can be used in research on cancers such as pancreatic cancer and neurological diseases such as Parkinson's disease.

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CAS No.: 1357362-67-4
Formule: C₂₀H₁₅NO₇S₃
Masse moléculaire:477.53

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

NOSH-aspirin Chemical Structure

CAS No.: 1357362-67-4

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform NF-κB :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	50 nM Compound: NOSH-1	Cytotoxicity against human A549 cells after 24 hrs by MTT assay Cytotoxicity against human A549 cells after 24 hrs by MTT assay	[PMID: 22916316]
BXPC-3	IC₅₀	57 nM Compound: NOSH-1	Cytotoxicity against human BxPC3 cells expressing COX1 and COX2 after 24 hrs by MTT assay Cytotoxicity against human BxPC3 cells expressing COX1 and COX2 after 24 hrs by MTT assay	[PMID: 22916316]
HCT-15	IC₅₀	50 nM Compound: NOSH-1	Cytotoxicity against COX deficient human HCT15 cells after 24 hrs by MTT assay Cytotoxicity against COX deficient human HCT15 cells after 24 hrs by MTT assay	[PMID: 22916316]
HCT-15	IC₅₀	57 nM Compound: 1	Cytotoxicity against human HCT15 cells assessed as growth inhibition after 24 hrs by MTT assay Cytotoxicity against human HCT15 cells assessed as growth inhibition after 24 hrs by MTT assay	[PMID: 26323873]
HT-29	IC₅₀	48 nM Compound: 1	Cytotoxicity against human HT-29 cells assessed as growth inhibition after 24 hrs by MTT assay Cytotoxicity against human HT-29 cells assessed as growth inhibition after 24 hrs by MTT assay	[PMID: 26323873]
HT-29	IC₅₀	48 nM Compound: NOSH-1	Cytotoxicity against human HT-29 cells expressing COX1 and COX2 after 24 hrs by MTT assay Cytotoxicity against human HT-29 cells expressing COX1 and COX2 after 24 hrs by MTT assay	[PMID: 22916316]
Jurkat	IC₅₀	100 nM Compound: NOSH-1	Cytotoxicity against human Jurkat cells expressing COX1 and COX2 after 24 hrs by MTT assay Cytotoxicity against human Jurkat cells expressing COX1 and COX2 after 24 hrs by MTT assay	[PMID: 22916316]
LNCaP	IC₅₀	88 nM Compound: NOSH-1	Cytotoxicity against human LNCAP cells after 24 hrs by MTT assay Cytotoxicity against human LNCAP cells after 24 hrs by MTT assay	[PMID: 22916316]
MCF7	IC₅₀	280 nM Compound: NOSH-1	Cytotoxicity against human MCF7 cells expressing ER after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells expressing ER after 24 hrs by MTT assay	[PMID: 22916316]
MDA-MB-231	IC₅₀	100 nM Compound: NOSH-1	Cytotoxicity against ER deficient human MDA-MB-231 cells after 24 hrs by MTT assay Cytotoxicity against ER deficient human MDA-MB-231 cells after 24 hrs by MTT assay	[PMID: 22916316]
MIA PaCa-2	IC₅₀	47 nM Compound: NOSH-1	Cytotoxicity against COX deficient human MIAPaCa2 cells after 24 hrs by MTT assay Cytotoxicity against COX deficient human MIAPaCa2 cells after 24 hrs by MTT assay	[PMID: 22916316]
SK-BR-3	IC₅₀	75 nM Compound: NOSH-1	Cytotoxicity against ER deficient human SKBR3 cells after 24 hrs by MTT assay Cytotoxicity against ER deficient human SKBR3 cells after 24 hrs by MTT assay	[PMID: 22916316]
SW480	IC₅₀	60 nM Compound: NOSH-1	Cytotoxicity against human SW480 cells expressing COX1 after 24 hrs by MTT assay Cytotoxicity against human SW480 cells expressing COX1 after 24 hrs by MTT assay	[PMID: 22916316]

Chemical Information

CAS No. 1357362-67-4
Masse moléculaire 477.53
Formule C₂₀H₁₅NO₇S₃
SMILES

O=C(OC1=CC=C(C(SS2)=CC2=S)C=C1)C3=CC=CC=C3OC(CCCO[N+]([O-])=O)=O
Synonyms

NBS-1120
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lee M, et al. NOSH-aspirin (NBS-1120), a novel nitric oxide and hydrogen sulfide releasing hybrid, attenuates neuroinflammation induced by microglial and astrocytic activation: a new candidate for treatment of neurodegenerative disorders. Glia. 2013 Oct;61(10):1724-34. [Content Brief]

[2]. Chattopadhyay M, et al. NOSH-aspirin (NBS-1120) inhibits pancreatic cancer cell growth in a xenograft mouse model: Modulation of FoxM1, p53, NF-κB, iNOS, caspase-3 and ROS. Biochem Pharmacol. 2020 Jun;176:113857. [Content Brief]

[3]. Firouzan B, et al. NOSH-aspirin (NBS-1120) attenuates motor defects and dopaminergic neuron degeneration in a rat model of Parkinson's disease. Eur J Pharmacol. 2025 Sep 5;1002:177733. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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