1 Result for "

NDI-Lyso

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "NDI-Lyso" in MCE Product Catalog:

NDI-Lyso
NDI-Lyso
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Cat. No.: HY-P10669
CAS No.: 2999646-19-2
Target:  

Caspase Apoptosis

Research Areas:  

Cancer

NDI-Lyso is a lysosome-targeted anticancer agent that induces the formation of rigid long fibers in cancer cell lysosomes through an enzyme-instructed self-assembly (EISA) mechanism catalyzed by cathepsin B. This process triggers lysosomal swelling, membrane permeabilization (LMP), and membrane disruption, ultimately leading to cancer cell apoptosis via a non-classical caspase-independent pathway. NDI-Lyso exhibits significant selective anticancer activity in various cancer cell lines and drug-resistant cancer cells (IC50 ~10 μM) while showing low toxicity to normal cells (IC50 > 60 μM) .
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