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Results for "

NUDT5

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Recombinant Proteins

1

Antibodies

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125209
    TH5427

    		DNA/RNA Synthesis Cancer
    TH5427 is a promising, targeted inhibitor that can be used to further study NUDT5 activity and ADP-ribose metabolism. TH5427, blocks progestin-dependent, PAR-derived nuclear ATP synthesis and subsequent chromatin remodeling, gene regulation and proliferation in breast cancer cells. NUDT5 is recently identified as a rheostat of hormone-dependent gene regulation and proliferation in breast cancer cells .
    TH5427
  • HY-16965
    TH287
    3 Publications Verification

    		 DNA/RNA Synthesis Cancer
    TH287 is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 could act as a chemotherapeutic agent for cancer research .
    TH287
  • HY-158318
    NUDT5/14 antagonist 1

    		DNA/RNA Synthesis Cancer
    NUDT5/14 antagonist 1 (Compound 9) is a selective, dual antagonist for nucleotide diphosphate kinase NUDT5 and NUDT14, with IC50 of 0.27 and 0.16 μM, respectively. NUDT5/14 antagonist 1 binds to Bruton’s tyrosine kinase (BTK) with an IC50 of 0.377 μM .
    NUDT5/14 antagonist 1
  • HY-125209A
    TH5427 hydrochloride

    		Apoptosis PARP DNA/RNA Synthesis Cancer
    TH5427 hydrochloride is a NUDT5 inhibitor with a human target IC50 of 29 nM, ~690-fold selectivity over MTH1 in vitro, and selective functional inhibition over other NUDIX hydrolases including NUDT9 .TH5427 hydrochloride binds to the active site of NUDT5, blocking enzymatic activity related to ADP-ribose metabolism and PAR-derived ATP synthesis .TH5427 hydrochloride blocks progestin-dependent nuclear ATP synthesis, impairs progestin-induced chromatin remodeling, inhibits histone H1 displacement, disrupts progestin-dependent gene regulation, and abrogates progestin-dependent proliferation in breast cancer cells .TH5427 hydrochloride functions as a versatile probe to study nuclear ATP dynamics and ADP-ribose-related metabolism in cells .TH5427 hydrochloride engages NUDT5 at physiological temperatures, as demonstrated by Drug Affinity Responsive Target Stability (DARTS) assay .TH5427 hydrochloride stabilizes NUDT5 against thermal denaturation in cell lysates and intact cells, as shown by cellular thermal shift assay (CETSA) .TH5427 hydrochloride functionally inhibits NUDT5 activity, leading to downstream effects on oxidative DNA damage and DNA replication in triple-negative breast cancer (TNBC) cells .TH5427 hydrochloride suppresses proliferation of TNBC cells without inducing cell death or apoptosis, slows DNA replication in TNBC cells, promotes accumulation of oxidative DNA lesions, and triggers DNA damage response in TNBC cells .TH5427 hydrochloride suppresses growth of TNBC cells in vitro, inhibits growth of TNBC xenograft tumors in nude mice in vivo, and shows greater potency against TNBC cell lines compared to ER-positive and normal-like breast cell lines .TH5427 hydrochloride can be used for the research of breast cancer and triple-negative breast cancer .
    TH5427 hydrochloride
  • HY-RS17917
    Nudt5 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nudt5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nudt5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nudt5 Mouse Pre-designed siRNA Set A
    Nudt5 Mouse Pre-designed siRNA Set A
  • HY-RS09673
    NUDT5 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    NUDT5 Human Pre-designed siRNA Set A contains three designed siRNAs for NUDT5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    NUDT5 Human Pre-designed siRNA Set A
    NUDT5 Human Pre-designed siRNA Set A
  • HY-RS24386
    Nudt5 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Nudt5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Nudt5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Nudt5 Rat Pre-designed siRNA Set A
    Nudt5 Rat Pre-designed siRNA Set A
  • HY-176261
    DDD2

    		PROTACs Cancer
    DDD2 is a selective and potent VHL-mediated PROTAC NUDT5 degrader. DDD2 induces robust NUDT5 degradation. DDD2 can be used in cancer research, such as lymphocytic leukemia and osteosarcoma . (Structure Note: Pink: NUDT5 inhibitor (HY-176262); Blue: E3 (HY-125845); Black: linker (HY-W001958))
    DDD2
  • HY-176262
    TH10184

    		Ligands for Target Protein for PROTAC Cancer
    TH10184 is a NUDT5 inhibitor. TH10184 can be conjugated with VH032 (HY-125845) and linker (HY-W001958) to synthesize PROTAC NUDT5 degrader DDD2 (HY-176261) .
    TH10184
  • HY-176263
    TH10184-octanedioic acid

    		Target Protein Ligand-Linker Conjugates Cancer
    TH10184-octanedioic acid is a conjugate of the NUDT5 ligand (HY-176262) and the linker (HY-W001958). TH10184-octanedioic acid can be used for synthesizing PROTAC NUDT5 degrader DDD2 (HY-176261) .
    TH10184-octanedioic acid
  • HY-16965A
    TH287 hydrochloride

    		DNA/RNA Synthesis Cancer
    TH287 hydrochloride is a potent and selective inhibitor of MTH1, with an IC50 of 0.8 nM. TH287 hydrochloride is highly selective towards MTH1, with no relevant inhibition of MTH2, NUDT5, NUDT12, NUDT14, NUDT16, dCTPase, dUTPase and ITPA at 100 μM. TH287 hydrochloride could act as a chemotherapeutic agent for cancer research .
    TH287 hydrochloride

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