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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
37 Results for "
Neurofilament
" in MedChemExpress (MCE) Product Catalog:
Products (37)
37 Results for "Neurofilament" in MCE Product Catalog:
2
2 Cited Publications
Synonyms: BIIB067; ISIS-SOD1Rx; ISIS 333611
Target:
Research Areas:
Tofersen (BIIB067) is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
2
2 Cited Publications
Synonyms: BIIB067 sodium; ISIS-SOD1Rx sodium; ISIS 333611 sodium
Target:
Research Areas:
Tofersen (BIIB067) sodium is an antisense oligonucleotide and SOD1 mRNA inhibitor with an IC50 of 320 pM. Tofersen sodium mediates RNase H-dependent degradation of SOD1 mRNA to reduce SOD1 protein levels in cerebrospinal fluid and serum. Tofersen sodium downregulates cerebrospinal fluid neurofilament light chain, neurofilament heavy chain, amyloid-beta 1-40, amyloid-beta 1-42, neuropeptide Y, ubiquitin C-terminal hydrolase L1, neuropentraxins 1, 2, R, corticotropin-releasing hormone, IL-15, and serum neurofilament light chain, neurofilament heavy chain. Tofersen sodium can be used for the research of superoxide dismutase 1-associated amyotrophic lateral sclerosis .
Research Areas:
Hexane-2,5-dione (2,5-HD) is an orally active, CNS-penetrant cytotoxic agent . Hexane-2,5-dione reduces BCL-2 and β-catenin/TCF transcriptional activity, increases BAX and active caspase-3 expression, and promotes apoptosis. Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats. Hexane-2,5-dione can be used for the research of neurodegenerative diseases .
Cat. No.: HY-173276
CAS No.: 3069378-18-0
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SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL). SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of SARM1, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.).
Cat. No.: HY-176305S
Cat. No.: HY-W611371
CAS No.: 61694-81-3
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FP802 is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology . FP802 stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS). FP802 can be used for AD and ALS research .
Cat. No.: HY-176783
CAS No.: 3080315-83-6
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Research Areas:
GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research .
Cat. No.: HY-132580S
Synonyms: BIIB067-d27; ISIS-SOD1Rx-d27; ISIS 333611-d27
Cat. No.: HY-W611371A
CAS No.: 2490401-57-3
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Research Areas:
FP802 dihydrochloride is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 dihydrochloride exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology . FP802 dihydrochloride stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS) . FP802 dihydrochloride can be used for AD and ALS research .
Cat. No.: HY-Y0315S
CAS No.: 97135-07-4
Synonyms: 2,5-HD-d10
Cat. No.: HY-176304S
Cat. No.: HY-P86702
Synonyms: Neurofilament L; Neurofilament 68; Neurofilament triplet L; 70 kD Neurofilament Light; 68kDa Neurofilament protein; CMT 1F; CMT 2E; CMT1F; CMT2E; FLJ53642; Light molecular weight Neurofilament protein; NEFL; Neurofilament light; Neurofilament light polypeptide 68kDa; Neurofilament light polypeptide; Neurofilament protein, light chain; Neurofilament subunit NF L; Neurofilament triplet L protein; NF 68; NF L; NF68; NFL; NFL_HUMAN.
Cat. No.: HY-P72305
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NEFL; Light Molecular Weight Neurofilament Protein; Neurofilament Light Chain; Neurofilament Light Polypeptide Isoform 1; NF68; Neurofilament Light Polypeptide Isoform 2; NFL; Neurofilament Protein, Light Chain; PPP1R110; Neurofilament, Light Polypeptide; CMT1F; 68 KDa Neurofilament Protein; CMT2E; Neurofilament Subunit NF-L; Protein Phosphatase 1, Regulatory Subunit 110; Neurofilament Light; Neurofilament, Light Polypeptide 68kDa; Neurofilament-Light; Neurofilament Light Polypeptide; NEFL Protein; Neurofilament Triplet L Protein; CMTDIG; NF-L
Cat. No.: HY-P704813
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NEFL; Light Molecular Weight Neurofilament Protein; Neurofilament Light Chain; Neurofilament Light Polypeptide Isoform 1; NF68; Neurofilament Light Polypeptide Isoform 2; NFL; Neurofilament Protein, Light Chain; PPP1R110; Neurofilament, Light Polypeptide
Cat. No.: HY-P72265
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: NEFL; Light Molecular Weight Neurofilament Protein; Neurofilament Light Chain; Neurofilament Light Polypeptide Isoform 1; NF68; Neurofilament Light Polypeptide Isoform 2; NFL; Neurofilament Protein, Light Chain; PPP1R110; Neurofilament, Light Polypeptide
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
