97135-07-4
Chemical Structure
2,5-Hexanedione-d10
Synonym(s): 2,5-HD-d10
- CAS No.: 97135-07-4
- Formula:C6D10O2
- Molecular Weight:124.20
IUPAC Name: 4-chloro-3-methylphen-2,6-d2-ol
InChIKey: OJVAMHKKJGICOG-MWUKXHIBSA-N
SMILES: [2H]C([2H])([2H])C(C([2H])([2H])C([2H])([2H])C(C([2H])([2H])[2H])=O)=O
Biological Activity: 2,5-Hexanedione-d10 (2,5-HD-d10) is the deuterium labeled 2,5-Hexanedione. Hexane-2,5-dione (2,5-HD) is an orally active, CNS-penetrant cytotoxic agent. Hexane-2,5-dione reduces BCL-2 and β-catenin/TCF transcriptional activity, increases BAX and active caspase-3 expression, and promotes apoptosis. Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats. Hexane-2,5-dione can be used for the research of neurodegenerative diseases[1][2][3][4][5][6][7].
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2,5-Hexanedione-d10 | 2,5-Hexanedione-d10 (2,5-HD-d10) is the deuterium labeled 2,5-Hexanedione. Hexane-2,5-dione (2,5-HD) is an orally active, CNS-penetrant cytotoxic agent. Hexane-2,5-dione reduces BCL-2 and β-catenin/TCF transcriptional activity, increases BAX and active caspase-3 expression, and promotes apoptosis. Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats. Hexane-2,5-dione can be used for the research of neurodegenerative diseases. | |||||||||||||||||||||
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Hexane-2,5-dione | 99.96% | Hexane-2,5-dione (2,5-HD) is an orally active, CNS-penetrant cytotoxic agent. Hexane-2,5-dione reduces BCL-2 and β-catenin/TCF transcriptional activity, increases BAX and active caspase-3 expression, and promotes apoptosis. Hexane-2,5-dione causes an accumulation of neurofilaments within axons in rats. Hexane-2,5-dione can be used for the research of neurodegenerative diseases. | ||||||||||||||||||||
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- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Sun Y, et al. 2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways. Arch Toxicol. 2012 Feb;86(2):205-15. [Content Brief]
- [3]. DeCaprio AP, et al. Comparative neurotoxicity and pyrrole-forming potential of 2,5-hexanedione and perdeuterio-2,5-hexanedione in the rat. Toxicol Appl Pharmacol. 1988 Jan;92(1):75-85. [Content Brief]
- [4]. Boekelheide K, et al. 2,5-hexanedione-induced testicular injury. Annu Rev Pharmacol Toxicol. 2003;43:125-47. [Content Brief]
- [5]. Planas AM, et al. Uncoupling of cerebral glucose supply and utilization after hexane-2,5-dione intoxication in the rat. J Neurochem. 1987 Mar;48(3):816-23. [Content Brief]
- [6]. Xu X, et al. The Wnt/β-catenin pathway is involved in 2,5-hexanedione-induced ovarian granulosa cell cycle arrest. Ecotoxicol Environ Saf. 2023 Dec;268:115720. [Content Brief]
- [7]. Pereira ME, et al. 2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro. Toxicol Lett. 2004 Feb 2;146(3):269-74. [Content Brief]
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