2,5-hexanedione-induced testicular injury

  • Annu Rev Pharmacol Toxicol. 2003:43:125-47. doi: 10.1146/annurev.pharmtox.43.100901.135930.
Kim Boekelheide  1 ,  Shawna L Fleming ,  Theresa Allio ,  Michelle E Embree-Ku ,  Susan J Hall ,  Kamin J Johnson ,  Eun Ji Kwon ,  Sutchin R Patel ,  Reza J Rasoulpour ,  Heidi A Schoenfeld ,  Stephanie Thompson
Affiliations
  • 1. Department of Pathology and Laboratory Medicine, Brown University, Providence, Rhode Island 02912, USA. [email protected]
PMID: 12471174 DOI: 10.1146/annurev.pharmtox.43.100901.135930
Abstract

Now in its third decade of mechanistic investigation, testicular injury caused by 2,5-hexanedione (2,5-HD) exposure is a well-studied model with a rich database. The development of this model reflects the larger changes that have moved biology from a branch of chemistry into the molecular age. Critically examined in this review is the proposed mechanism for 2,5-HD-induced testicular injury in which germ cell maturation is disrupted owing to alterations in Sertoli cell microtubule-mediated functions. The goal is to evaluate the technical and conceptual approaches used to assess 2,5-HD-induced testicular injury, to highlight unanswered questions, and to identify fruitful avenues of future research.

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