3080315-83-6
3080315-83-6
Chemical Structure
GNE-5152
- CAS No.: 3080315-83-6
- Formula:C21H17F2N3O
- Molecular Weight:365.38
SMILES: O=C1N(CCC(C1)C2=CC=C(C(F)=C2)F)C3=CC=C(C4=CC=NC=C4)N=C3
Biological Activity: GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
GNE-5152 | GNE-5152 is an orthosteric SARM1 base-exchange (BE) inhibitor. GNE-5152 sustainably activates SARM1 at subinhibitory concentrations under mildly activating conditions, and this synergistic adverse effect increases NAD consumption, induces axon degradation and neurodegeneration and releases neurofilament-light (NfL) in cortical neurons. GNE-5152 can be used for neurodegenerative diseases research. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
