Peripherin Antibody (YA5388)
(Synonyms: Peripherin; Neurofilament 4; )
Based on 1 Customer Validation
Peripherin Antibody (YA5388) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Peripherin.
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Host:
Mouse
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Application:
WB
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Reactivity :
Human, Rat
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Formulation:
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000-2000 |
Product Details
Peripherin Antibody (YA5388) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Peripherin.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Synthesized peptide derived from human Peripherin
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Peripherin is a Class-III neuronal intermediate filament protein. May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form a filamentous network. Assembly of the neuronal intermediate filaments may be regulated by RAB7A. Plays a role in the development of unmyelinated sensory neurons. May be involved in axon elongation and axon regeneration after injury. Inhibits neurite extension in type II spiral ganglion neurons in the cochlea[1][2].
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Subcellular Localization
Cytoplasm, cytoskeleton; Cell projection, axon; Perikaryon
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Expression
Tissue_specificity:Expressed in the neurons of the outer hair cells in the organ of Corti and to a lesser extent in type I spiral ganglion cells -
Isoforms & Post-Translational Modification
P41219 has 2 isomers: P41219-1: 53651 Da (predicted); P41219-2: 53779 Da (predicted).
Phosphorylated; phosphorylation increases after nerve injury in regenerating neurons -
Subunit
Forms homodimers (in vitro) (By similarity). Homopolymerizes into a filamentous network (in vitro) (PubMed:15446584). Forms heterodimers with NEFL, NEFM or NEFH (in vitro) (By similarity). Interacts with DST (via C-terminus) (By similarity). Interacts with RAB7A; the interaction is direct (PubMed:23179371). Interacts with PRKCE (via phorbol-ester/DAG-type 2 domain) (PubMed:18408015)
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SwissProt ID
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Synonyms
Peripherin; Neurofilament 4;
Documentation
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