3069378-18-0
Chemical Structure
SARM1-IN-4
- CAS No.: 3069378-18-0
- Formula:C13H17F2N3O2
- Molecular Weight:285.29
InChIKey: BDCYNMOBTJPEHV-GXSJLCMTSA-N
SMILES: C[C@@H](C1=CC=NC=C1)N(C(N[C@@H]2COCC2(F)F)=O)C
Biological Activity: SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL). SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of SARM1, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.).
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SARM1-IN-4 | SARM1-IN-4 (Compound 7) is an orally active SARM1 inhibitor. After being orally administered at a dose of 50 mg/kg in a mouse model, it can reduce the level of plasma neurofilament light chain (NfL). SARM1-IN-4 prevents programmed axonal degeneration by inhibiting the NAD+ hydrolase activity of SARM1, and it can be used in research related to neurodegenerative diseases and neurological disorders (such as multiple sclerosis, amyotrophic lateral sclerosis, Parkinson's disease, and peripheral neuropathies, etc.). | |||||||||||||||||||||
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Keywords
