Neurofilament light polypeptide/NEFL, Mouse (His)

Neurofilament light chain polypeptide (NEFL) is a part of neurofilaments that, in cooperation with NEFM and NEFH, form the structural basis of neurons.It maintains neuronal caliber and assembles filamentous networks with PRPH and INA.Neurofilament light polypeptide/NEFL, Mouse (His) is the recombinant mouse-derived Neurofilament light polypeptide/NEFL, expressed by E.coli , with N-His labeled tag.

Neurofilament light polypeptide (NEFL), a component of neurofilaments, typically collaborates with the intermediate filament proteins NEFM and NEFH to maintain neuronal caliber, forming a structural foundation in neurons. In conjunction with neuronal intermediate filament proteins such as PRPH and INA, NEFL may participate in the assembly of neuronal filamentous networks. In vitro, NEFL demonstrates the ability to form homodimers and engage in heterodimerization with NEFH or NEFM, further forming hetero-oligomers. Additionally, NEFL forms heterodimers with INA. Its interactions extend to regulatory relationships, as evidenced by its association with ARHGEF28 and TRIM2, emphasizing the intricate molecular interplay involved in shaping neuronal structural integrity.

Mouse

E. coli

N-His

P08551 (S2-D543)

18039  [NCBI]

Full Length of Mature Protein

SSFGYDPYFSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEIAFLKKVHEEEIAELQAQIQYAQISVEMDVSSKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRSTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYSGLQSSSYLMSARSFPAYYTSHVQEEQTEVEETIEATKAEEAKDEPPSEGEAEEEEKEKEEGEEEEGAEEEEAAKDESEDTKEEEEGGEGEEEDTKESEEEEKKEESAGEEQVAKKKD

Approximately 68 kDa, based on SDS-PAGE under reducing conditions.

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  ≥ 90%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.