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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
26 Results for "
OHCs
" in MedChemExpress (MCE) Product Catalog:
Products (26)
26 Results for "OHCs" in MCE Product Catalog:
31
Target:
10
4
Target:
1
Category:
Disease markers Metabolic Disease Nervous System Disorder Endogenous metabolite Disease Research Fields Steroids
Target:
1
1 Cited Publications
Synonyms: GPR183 antagonist-1
Target:
Research Areas:
SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC50 value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC50 value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice .
Cat. No.: HY-138115
CAS No.: 240129-43-5
Synonyms: 7β, 27-OHC
Target:
Research Areas:
7ß,27-Dihydroxycholesterol (7β, 27-OHC) is a potent and selective activator of RORγt (Ki=120 nM). 7ß,27-Dihydroxycholesterol promotes the differentiation of mouse and human CD4 + Th17 cells. 7ß,27-Dihydroxycholesterol also increases the production of IL-17 depended on CYP27A1 .
Synonyms: 25-OHC-d6
Synonyms: 3-OH-C4-HSL; N-3-Hydroxybutanoyl-L-homoserine lactone; N-3-Hydroxybutyryl-L-HSL
N-3-Hydroxybutyryl-L-homoserine lactone (3-OH-C4-HSL) is an acyl-homoserine lactone, that can be isolated from Vibrionaceae. N-3-Hydroxybutyryl-L-homoserine lactone is a signaling molecule that is involved in bacterial quorum sensing (QS). N-3-Hydroxybutyryl-L-homoserine lactone senses the density of bacterial population, regulates the cellular process, such as bioluminescence, biofilm formation, and exo-enzyme production .
Cat. No.: HY-P11350
Cat. No.: HY-N2371R
CAS No.: 20380-11-4
Synonyms: 27-OHC (Standard)
Cat. No.: HY-16940A
CAS No.: 27460-26-0
Synonyms: 24R-OHC; 24R-HC; 24(R)-Cerebrosterol
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Research Areas:
24(R)-Hydroxycholesterol (24R-OHC) is a key intermediate of Tacalcitol (HY-32337) .
Cat. No.: HY-P11350A
Cat. No.: HY-113962S
CAS No.: 2260669-11-0
Synonyms: 7α,25-OHC-d6
Cat. No.: HY-W1048574E
Synonyms: OHC-PEG20000-carboxyl
Cat. No.: HY-W1048574I
Synonyms: OHC-PEG3400-carboxyl
Cat. No.: HY-133974
CAS No.: 64907-23-9
Synonyms: 7-keto-25-OHC
7-keto-25-Hydroxycholesterol (7-keto-25-OHC), a oxysterol, is a Smoothened (Smo) activator. 7-keto-25-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo .
Cat. No.: HY-113134R
CAS No.: 2140-46-7
Synonyms: 25-OHC (Standard)
Category:
Cat. No.: HY-400897
CAS No.: 1326612-12-7
Research Areas:
7α,25-Dihydroxycholesterol intermediate-1 is an intermediate in the synthesis of 7α,25-Dihydroxycholesterol (HY-113962). 7α,25-Dihydroxycholesterol (7α,25-OHC) can be used as a ligand to target the orphan GPCR receptor EBI2 (GPR183). body, used to synthesize the corresponding PROTEACs .
Cat. No.: HY-163903
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OH-C2-PEG3-NHCO-C3-COOH is a PROTAC linker that can be used in the synthesis of PROTACs .
Cat. No.: HY-174087
CAS No.: 3071165-50-6
Research Areas:
Thalidomide-4-OH-C11-OH is an E3 Ligase Ligand-Linker Conjugate, which is composed of Thalidomide-4-OH (HY-103596) and the corresponding Linker. Thalidomide-4-OH-C11-OH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules, such as PROTAC GPX4 degrader-4 (HY-174086) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
