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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
PA-1
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "PA-1" in MCE Product Catalog:
Cat. No.: HY-P10352A
Cat. No.: HY-P10352
CAS No.: 111745-56-3
Synonyms: 16:0-18:1 PA
Cat. No.: HY-W725309
CAS No.: 384833-24-3
Synonyms: 1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate sodium
Cat. No.: HY-128850S1
CAS No.: 875654-27-6
Synonyms: N-Acetylmannosamine-13C; ManNAc-13C
Cat. No.: HY-125667
CAS No.: 1620951-72-5
Synonyms: Photoamiloride-1
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PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively [1].
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Cat. No.: HY-145486
CAS No.: 799268-65-8
Synonyms: 20:4 Lyso PA
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1-Arachidonoyl-sn-glycerol 3-phosphate ammonium (20:4 Lyso PA) is a phospholipid and an LPA derived from arachidonic acid. The concentration of 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium in plasma is significantly correlated with the age of onset of cocaine use and the duration of abstinence. 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium can be used in the research of biomarkers for cocaine use disorder (CUD) [1].
Cat. No.: HY-143407
CAS No.: 2882094-29-1
FAK-IN-3 (Compound 36) is a potent inhibitor of focal adhesion kinase (FAK). FAK-IN-3 not only decreases migration and invasion of PA-1 cells, but also reduces expression of MMP-2 and MMP-9. FAK-IN-3 inhibits tumor growth and metastasis, and no obvious adverse effects. FAK-IN-3 has the potential for the research of ovarian cancer [1].
Cat. No.: HY-P991311
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Cat. No.: HY-177782
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SB1349 is a molecular glucose degrading agent that targets the Lin28 protein. SB1349 can effectively induce proteasome dependent degradation of Lin28A and Lin28B. SB1349 can increase the level of mature let-7 miRNA, downregulate the oncogenes targeted by let-7, and effectively induce the differentiation of neuroblastoma cells. SB1349 can be used for cancer research [1].
Cat. No.: HY-177497
CAS No.: 2852050-29-2
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SKLB-03220 is a selective and orally active EZH2 covalent inhibitor with an IC50 of 1.72 nM for EZH2 MUT. SKLB-03220 exhibits weak activities against other tested histone methyltransferases (HMTs) and kinases. SKLB-03220 displays noteworthy potency against ovarian cancer cell lines and induces cell apoptosis. SKLB-03220 significantly inhibits tumor growth in PA-1 xenograft model. SKLB-03220 can be used for the study of ovarian cancer [1].
Cat. No.: HY-175459
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PROTAC FAK degrader 3 is a selective FAK PROTAC degrader (DC50 = 1.08 nM). PROTAC FAK degrader 3 induces FAK degradation dependent on the ubiquitin-proteasome system and its binding to FAK and CRBN. PROTAC FAK degrader 3 upregulates MHC-I gene transcription and tumor cell surface expression by inhibiting the non-catalytic activity of FAK, leading to increased antigen presentation and activation of cytotoxic CD8 T cells. PROTAC FAK degrader 3 enhances in vivo anti-tumor activity by promoting MHC-I expression and enhancing T cell activation. PROTAC FAK degrader 3 can be used in cancer research targeting FAK degradation in ovarian cancer, hepatocellular carcinoma, and other cancers [1].
Cat. No.: HY-128850S5
Synonyms: N-Acetylmannosamine-15N; ManNAc-15N
Cat. No.: HY-W747907
CAS No.: 4753-19-9
Synonyms: β-Pyracin
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Cat. No.: HY-N15109
CAS No.: 336625-36-6
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Cat. No.: HY-RS09978
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PAGR1 Human Pre-designed siRNA Set A contains three designed siRNAs for PAGR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-131574
CAS No.: 31701-88-9
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
