1620951-72-5
1620951-72-5
Chemical Structure
PA1
Synonym(s): Photoamiloride-1
- CAS No.: 1620951-72-5
- Formula:C18H16ClN9O
- Molecular Weight:409.83
IUPAC Name: (E)-3,5-diamino-6-chloro-N-(N-(4-(phenyldiazenyl)phenyl)carbamimidoyl)pyrazine-2-carboxamide
InChIKey: FGRHJWDUHPWDDC-BYYHNAKLSA-N
SMILES: O=C(NC(NC1=CC=C(C=C1)/N=N/C2=CC=CC=C2)=N)C3=NC(Cl)=C(N=C3N)N
Biological Activity: PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively[1].
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PA1 | PA1 is a photoswitchable epithelial sodium channel (ENaC) blocker. PA1 can switch to cis-PA1 at 400nm and trans-PA1 at 500nm. PA1 inhibits δ/αENaC, αβγENaC, and δβγENaC, with IC50 values of 4.3nM, 90 nM, and 390 nM, respectively. | |||||||||||||||||||||
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References
Keywords
