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Results for "

PI3Kα Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Akt (18) Apoptosis (42) ATM/ATR (3) Autophagy (9) Bcl-2 Family (1) Bcr-Abl (1) c-Myc (1) Cadherin (1) Casein Kinase (2) Caspase (1) CD3 (1) CDK (5) DNA-PK (7) Dopamine Receptor (3) Drug Intermediate (2) EGFR (2) Epigenetic Reader Domain (5) ERK (2) HDAC (7) HIF/HIF Prolyl-Hydroxylase (1) Histone Methyltransferase (1) HSP (1) Interleukin Related (1) Isotope-Labeled Compounds (2) MAP4K (1) MEK (3) Mitochondrial Metabolism (1) MMP (1) mTOR (61) NF-κB (1) P-glycoprotein (1) p38 MAPK (1) PAK (1) Paraptosis (1) Parasite (1) PARP (2) PD-1/PD-L1 (1) PERK (3) Phosphatase (2) PI3K (171) PI4K (3) PPAR (1) PROTACs (1) Ras (5) Reactive Oxygen Species (ROS) (3) Reference Standards (15) SARS-CoV (1) Syk (1) VEGFR (1) Virus Protease (1) Wnt (1)
By Research Areas:	Cancer (170) Infection (7) Inflammation/Immunology (12) Metabolic Disease (5) Neurological Disease (8)

By Targets:

Adenosine Receptor (1)

Akt (18)

Apoptosis (42)

ATM/ATR (3)

Autophagy (9)

Bcl-2 Family (1)

Bcr-Abl (1)

c-Myc (1)

Cadherin (1)

Casein Kinase (2)

Caspase (1)

CD3 (1)

CDK (5)

DNA-PK (7)

Dopamine Receptor (3)

Drug Intermediate (2)

EGFR (2)

Epigenetic Reader Domain (5)

ERK (2)

HDAC (7)

HIF/HIF Prolyl-Hydroxylase (1)

Histone Methyltransferase (1)

HSP (1)

Interleukin Related (1)

Isotope-Labeled Compounds (2)

MAP4K (1)

MEK (3)

Mitochondrial Metabolism (1)

MMP (1)

mTOR (61)

NF-κB (1)

P-glycoprotein (1)

p38 MAPK (1)

PAK (1)

Paraptosis (1)

Parasite (1)

PARP (2)

PD-1/PD-L1 (1)

PERK (3)

Phosphatase (2)

PI3K (171)

PI4K (3)

PPAR (1)

PROTACs (1)

Ras (5)

Reactive Oxygen Species (ROS) (3)

Reference Standards (15)

SARS-CoV (1)

Syk (1)

VEGFR (1)

Virus Protease (1)

Wnt (1)

By Research Areas:

Cancer (170)

Infection (7)

Inflammation/Immunology (12)

Metabolic Disease (5)

Neurological Disease (8)

181

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101562

Inavolisib 5+ Cited Publications GDC-0077; RG6114	PI3K Apoptosis	Cancer
Inavolisib (GDC-0077) is a potent, orally active, and selective *PI3Kα* inhibitor (IC₅₀=0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3Kα. Inavolisib can be used for the study of breast cancer .

HY-10681

Gedatolisib 5 Publications Verification PKI-587; PF-05212384	PI3K mTOR	Cancer
Gedatolisib (PKI-587) is a highly potent dual inhibitor of *PI3Kα, PI3Kγ, and mTOR* with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively . Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .

HY-156681

Tersolisib 1 Publications Verification STX-478; STX-478-101; LY4064809	PI3K	Cancer
STX-478 (compound 80) is an oral CNS-penetrant allosteric mutant-selective *PI3Kα* inhibitor. STX-478 shows robust and durable tumor regression and can be used in cancer research .

HY-139609

Camonsertib 2 Publications Verification RP-3500; ATR Inhibitor 4	ATM/ATR mTOR	Cancer
Camonsertib (RP-3500) is an orally active, selective ATR kinase inhibitor (ATRi) with an IC₅₀ of 1.00 nM in biochemical assays. Camonsertib shows 30-fold selectivity for ATR over mTOR (IC₅₀=120 nM) and >2,000-fold selectivity over ATM, DNA-PK, and PI3Kα kinases. Camonsertib has potent antitumor activity .

HY-159852

BBO-10203	PI3K Ras Akt	Cancer
BBO-10203 is a potent inhibitor of *PI3Kα* and KRAS ^G12C, selectively and covalently binding to Cys242 in the RAS-Binding Domain of *PI3Kα, and inhibiting* both the GTP-bound and GDP-bound states of KRAS ^G12C with an IC₅₀ of 0.031 nM and an EC₅₀ of 0.02 nM. BBO-10203 disrupts the interaction between RAS isoforms and *PI3Kα, leading to the inhibition of RAS-mediated PI3Kα* activation, and reduces pERK expression, cell growth, and induces G₁ arrest and apoptosis. BBO-10203 can be used for the research of breast cancer, colorectal cancer, and non-small cell lung cancer .

HY-19962

Paxalisib 5 Publications Verification GDC-0084	PI3K mTOR	Cancer
Paxalisib (GDC-0084) is a brain penetrant inhibitor of *PI3K* and mTOR, with K_is of 2 nM, 46 nM, 3 nM, 10 nM and 70 nM for PI3Kα PI3Kβ, PI3Kδ, PI3Kγ and mTOR, respectively .

HY-13898

Taselisib 20+ Cited Publications GDC-0032; RG-7604	PI3K	Cancer
Taselisib (GDC-0032) is a potent *PI3K* inhibitor targets PIK3CA mutations, with K_is of 0.12 nM, 0.29 nM, 0.97 nM, and 9.1 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.

HY-12868

Bimiralisib 4 Publications Verification PQR309	PI3K mTOR	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Bimiralisib (PQR309) is a potent, brain-penetrant, orally bioavailable, pan-class I *PI3K/mTOR* inhibitor with IC₅₀s of 33 nM, 451 nM, 661 nM, 708 nM and 89 nM for *PI3Kα, PI3Kδ, PI3Kβ, PI3Kγ and mTOR, respectively. Bimiralisib is an mTORC1* and mTORC2 inhibitor.

HY-15177

PF-04691502 10+ Cited Publications	PI3K mTOR Autophagy	Cancer
PF-04691502 is a potent and selective inhibitor of *PI3K* and mTOR. PF-04691502 binds to human PI3Kα, β, δ, γ and mTOR with K_is of 1.8, 2.1, 1.6, 1.9 and 16 nM, respectively.

HY-100398

PF-04979064 2 Publications Verification	PI3K mTOR	Cancer
PF-04979064 is a potent and selective *PI3K/mTOR* dual kinase inhibitor with K_is of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.

HY-15174

Dactolisib Tosylate 65+ Cited Publications BEZ235 Tosylate; NVP-BEZ 235 Tosylate	PI3K mTOR Autophagy	Cancer
Dactolisib Tosylate (BEZ235 Tosylate) is a dual *PI3K* and mTOR kinase inhibitor with IC₅₀ values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.

HY-12046

PIK-93 5+ Cited Publications	PI4K PI3K Virus Protease	Cancer
PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC₅₀ of 19 nM, and also inhibits PI3Kγ and *PI3Kα* with IC₅₀ of 16 nM and 39 nM, respectively.

HY-173405

VVD-699	Ras PI3K Akt	Cancer
VVD-699 is a covalent blocker of the RAS-p110α interaction with oral activity. VVD-699 inhibits activation of *PI3Kα* (IC₅₀: 104 nM in H358 cells) . VVD-699 inhibits phosphorylated AKT. VVD-699 can be used for the research of KRAS mutant/amplified cancer .

HY-12330

AZD8186 5+ Cited Publications	PI3K	Cancer
AZD8186 is a *PI3K* inhibitor, which potently inhibits PI3Kβ (IC₅₀=4 nM) and PI3Kδ (IC50₅₀=12 nM) with selectivity over PI3Kα (IC₅₀=35 nM) and PI3Kγ (IC₅₀=675 nM).

HY-16596

CNX-1351	PI3K	Cancer
CNX-1351 is a potent and isoform-selective targeted covalent *PI3Kα* inhibitor with IC₅₀ of 6.8 nM.

HY-10683

PKI-402 10+ Cited Publications	PI3K mTOR	Cancer
PKI-402 is a selective, reversible, ATP-competitive inhibitor of *PI3K, including PI3K-α* mutants, and mTOR (IC₅₀=2, 3, 7,14 and 16 nM for PI3Kα, mTOR, PI3Kβ, PI3Kδ and PI3Kγ).

HY-101146

SF2523 2 Publications Verification	PI3K Epigenetic Reader Domain DNA-PK	Cancer
SF2523 is a highly selective and potent inhibitor of *PI3K* with IC₅₀s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for *PI3Kα, PI3Kγ, DNA-PK*, BRD4 and mTOR, respectively.

HY-16526

Pilaralisib 5 Publications Verification XL-147; SAR245408	PI3K	Cancer
Pilaralisib (XL147; SAR245408) is a potent and highly selective class I PI3Ks inhibitor with IC₅₀s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ.

HY-13334A

BGT226 5 Publications Verification NVP-BGT226	PI3K mTOR Autophagy	Cancer
BGT226 (NVP-BGT226) is a *PI3K* (with IC₅₀s of 4 nM, 63 nM and 38 nM for *PI3Kα, PI3Kβ and PI3Kγ)/mTOR* dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells .

HY-15856B

Flupentixol dihydrochloride 2 Publications Verification Flupenthixol dihydrochloride	Dopamine Receptor PI3K Apoptosis	Neurological Disease Cancer
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new *PI3K* inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research .

HY-15466

Izorlisib 3 Publications Verification CH5132799	PI3K	Cancer
Izorlisib (CH5132799) is a selective class I *PI3K* inhibitor. Izorlisib inhibits class I PI3Ks, particularly PI3Kα, with an IC₅₀ of 14 nM.

HY-12034

WYE-354 5+ Cited Publications	mTOR Autophagy Apoptosis	Cancer
WYE-354 is an ATP-competitive mTOR inhibitor with an IC₅₀ of 5 nM. WYE-354 also inhibits *PI3Kα* and PI3Kγ with IC₅₀s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro .

HY-13431

KU-0060648 4 Publications Verification	DNA-PK PI3K mTOR	Cancer
KU-0060648 is a dual inhibitor of *PI3K* and DNA-PK with IC₅₀s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively .

HY-10811

GNE-493 2 Publications Verification	PI3K mTOR	Cancer
GNE-493 is a potent, selective, and orally available dual pan-PI3-kinase/mTOR inhibitor with IC₅₀s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR.

HY-13334

BGT226 maleate 5 Publications Verification NVP-BGT226 maleate	PI3K mTOR Autophagy Apoptosis	Cancer
BGT226 (NVP-BGT226 maleate) is a *PI3K* (with IC₅₀s of 4 nM, 63 nM and 38 nM for *PI3Kα, PI3Kβ and PI3Kγ) /mTOR* dual inhibitor which displays potent growth-inhibitory activity against human head and neck cancer cells .

HY-101272

GDC-0326 1 Publications Verification	PI3K	Cancer
GDC-0326 is a potent and selective *PI3Kα* inhibitor with a K_i of 0.2 nM.

HY-12869

AZD-8835 1 Publications Verification	PI3K	Cancer
AZD8835 is a potent and selective inhibitor of *PI3Kα* and PI3Kδ with IC₅₀s of 6.2 and 5.7 nM, respectively.

HY-131972

PF-06843195	PI3K	Cancer
PF-06843195 is a highly selective *PI3Kα* inhibitor with an IC₅₀ of 18 nM in Rat1 fibroblasts. The K_is of PF-06843195 for *PI3Kα* and PI3Kδ in biochemical kinase assay are less than 0.018 nM and 0.28 nM, respectively. PF-06843195 has great suppression of the PI3K/mTOR signaling pathway and durable antitumor efficacy .

HY-15271

WYE-687 3 Publications Verification	mTOR PI3K	Cancer
WYE-687 is an ATP-competitive mTOR inhibitor with an IC₅₀ of 7 nM. WYE-687 concurrently inhibits activation of mTORC1 and mTORC2. WYE-687 also inhibits *PI3Kα* and PI3Kγ with IC₅₀s of 81 nM and 3.11 μM, respectively.

HY-13333

NVP-BAG956 BAG 956	PI3K	Cancer
NVP-BAG956 is an ATP-competitive *PI3K* inhibitor with IC50s of 34, 56, 112 and 444 nM for PI3Kδ, PI3Kα, PI3Kγ and PI3Kβ, respectively.

HY-107365

PQR530	PI3K mTOR	Cancer
PQR530 is a potent, ATP-competitive, orally bioavailable and brain-penetrant dual pan-PI3K/mTORC1/2 inhibitor, with a subnanomolar K_d toward PI3Kα and mTOR (0.84 and 0.33 nM, respectively). Antitumor activity .

HY-118712

WYE-23	mTOR	Cancer
WYE-23 is a mTOR inhibitor, and IC₅₀ is 0.45 nM. It is selective to PI3Kα and IC₅₀ is 661 nM. WYE-23 has antitumor activity .

HY-B1550

Benzoin DL-Benzoin; Desyl alcohol; (±)-2-Hydroxy-2-phenylacetophenone	PI3K	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Benzoin (DL-Benzoin) is a *PI3Kα* inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116) .

HY-13864

PF-4989216 1 Publications Verification	PI3K Apoptosis	Cancer
PF-4989216 is a potent and selective *PI3Kα* inhibitor with a K_i of 0.6 nM.

HY-12340

ETP-46321	PI3K	Cancer
ETP-46321 is a potent and orally bioavailable *PI3Kα* and PI3Kδ inhibitor with K_iapps of 2.3 and 14.2 nM, respectively.

HY-124036

DS-7423	PI3K mTOR	Cancer
DS-7423 is a dual *PI3K* and mTOR inhibitor, with IC₅₀ values of 15.6 nM, 34.9 nM for PI3Kα and mTOR, respectively. DS-7423 possesses anti-tumor activity .

HY-136198

SRX3207	Syk PI3K	Cancer
SRX3207 is an orally active and first-in-class dual *Syk/PI3K* inhibitor, with IC₅₀ values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression .

HY-112443

AZD3458	PI3K	Metabolic Disease Inflammation/Immunology Cancer
AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC₅₀s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, *PI3Kα, PI3Kβ, and PI3K*δ, respectively .

HY-143404

PI3K-IN-30 3 Publications Verification	PI3K	Cancer
PI3K-IN-30 (compound 6d) is a potent *PI3K* inhibitor with IC₅₀s of 5.1, 136, 30.7 and 8.9 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively .

HY-156681A

(S)-Tersolisib (S)-STX-478; (S)-STX-478-101; (S)-LY4064809	PI3K	Cancer
(S)-STX-478 is the S-enantiomer of STX-478. STX-478 is a selective inhibitor of *PI3Kα* mutants, preventing metabolic dysfunction and demonstrating antitumor activity in xenograft mouse models with *PI3Kα* mutant tumors .

HY-100470

NSC781406 2 Publications Verification	PI3K mTOR	Cancer
NSC781406 is a highly potent *PI3K* and mTOR inhibitor with an IC₅₀ of 2 nM for PI3Kα.

HY-11105

Pilaralisib analogue 1 Publications Verification XL147 analogue	PI3K Apoptosis	Cancer
Pilaralisib analogue (XL147 analogue) is a representative and selective *PI3Kα* inhibitor extracted from patent WO2012006552A1, Compound 147 in Table 1.

HY-150618

PI3Kα-IN-9 1 Publications Verification	PI3K Apoptosis	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
PI3Kα-IN-9 (compound 27) is a selective, long-acting and oral active **PI3Kα inhibitor with IC₅₀** values of 4.4, 128, 146 and 153 nM for PI3Kα, PI3Kγ, PI3Kδ and PI3Kβ, respectively. PI3Kα-IN-9 has antiproliferative activity and induces apoptosis. PI3Kα-IN-9 can be used for cancer research .

HY-147419

Vulolisib	PI3K	Cancer
Vulolisib is a potent and orally active phosphatidylinositol 3-kinase (PI3K) inhibitor, with IC₅₀ values of 0.2 nM, 168 nM, 90 nM and 49 nM for PI3Kα, PI3Kβ, PI3Kγ and PI3Kδ, respectively. Antiproliferative and antineoplastic activity .

HY-149669

PH14	PI3K HDAC Apoptosis	Cancer
PH14 is a dual *PI3K/HDAC* inhibitor with IC₅₀ values of 20.3 nM and 24.5 nM for *PI3Kα* and HDAC3, respectively. PH14 has antiproliferative activity and also induces apoptosis in Jeko-1 cells. PH14 can be used in cancer research, such as lymphoma .

HY-10681R

Gedatolisib (Standard)	PI3K mTOR Reference Standards	Cancer
Gedatolisib (Standard) is the analytical standard of Gedatolisib. This product is intended for research and analytical applications. Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC50s of 0.4 nM, 5.4 nM and 1.6 nM, respectively . Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .

HY-131345

PI3Kα-IN-4	PI3K	Cancer
PI3Kα-IN-4 is a potent, selective and orally active inhibitor of *PI3Kα, with an IC₅₀* of 1.8 nM. PI3Kα-IN-4 has antitumor activity .

HY-15174R

Dactolisib Tosylate (Standard) BEZ235 Tosylate (Standard); NVP-BEZ 235 Tosylate (Standard)	PI3K mTOR Autophagy Reference Standards	Cancer
Dactolisib (Tosylate) (Standard) is the analytical standard of Dactolisib (Tosylate). This product is intended for research and analytical applications. Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.

HY-118717

mTOR inhibitor WYE-28	mTOR	Cancer
mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC₅₀*)=0.08 nM. mTOR inhibitor* WYE-28 inhibits *PI3Kα* with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T_1/2) in nude mouse microsomes of 13 min .**

HY-15856A

Flupentixol Flupenthixol	Dopamine Receptor PI3K Apoptosis	Neurological Disease
Flupentixol is an orally active D₁/D₂ dopamine receptor antagonist and new *PI3K* inhibitor (PI3Kα IC₅₀=127 nM). Flupentixol shows anti-proliferative activity to cancer cells and induces apoptosis. Flupentixol can also be used in schizophrenia, anxiolytic and depressive research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1550

Benzoin DL-Benzoin; Desyl alcohol; (±)-2-Hydroxy-2-phenylacetophenone	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	PI3K
Benzoin (DL-Benzoin) is a *PI3Kα* inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116) .

HY-B1550R

Benzoin (Standard) DL-Benzoin (Standard); Desyl alcohol (Standard); (±)-2-Hydroxy-2-phenylacetophenone (Standard)	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Reference Standards PI3K
Benzoin (Standard) (DL-Benzoin (Standard)) is the analytical standard of Benzoin (HY-B1550). This product is intended for research and analytical applications. Benzoin (DL-Benzoin), a natural balsamic resin, is a *PI3Kα* inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116). Benzoin can be used as a food additive.

Cat. No.	Product Name	Chemical Structure

HY-B1550S

Benzoin-d10
Benzoin-d₁₀ (DL-Benzoin-d₁₀) is the deuterium labeled Benzoin (HY-B1550). Benzoin (DL-Benzoin), a natural balsamic resin, is a *PI3Kα* inhibitor with anticancer effects. Benzoin inihits the growth of colon cancer cell line (HCT-116). Benzoin can be used as a food additive .

HY-10681S

Gedatolisib-d8
Gedatolisib-d₈ (PKI-587-d₈) is the deuterium labeled Gedatolisib (HY-10681). Gedatolisib (PKI-587) is a highly potent dual inhibitor of PI3Kα, PI3Kγ, and mTOR with IC₅₀s of 0.4 nM, 5.4 nM and 1.6 nM, respectively. Gedatolisib is equally effective in both complexes of mTOR, mTORC1 and mTORC2 .

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