1062169-56-5
1062169-56-5
Chemical Structure
WYE-354
- CAS No.: 1062169-56-5
- Formula:C24H29N7O5
- Molecular Weight:495.53
IUPAC Name: methyl 4-(6-(4-((methoxycarbonyl)amino)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
InChIKey: IMXHGCRIEAKIBU-UHFFFAOYSA-N
SMILES: COC(NC1=CC=C(C=C1)C2=NC3=C(C(N4CCOCC4)=N2)C=NN3C5CCN(CC5)C(OC)=O)=O
Biological Activity: WYE-354 is an ATP-competitive mTOR inhibitor with an IC50 of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC50s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro[3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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WYE-354 | 98.03% | WYE-354 is an ATP-competitive mTOR inhibitor with an IC50 of 5 nM. WYE-354 also inhibits PI3Kα and PI3Kγ with IC50s of 1.89 μM and 7.37 μM, respectively. WYE-354 inhibits both mTORC1 and mTORC2. WYE-354 induces autophagy activation in vitro. | ||||||||||||||||||||
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References
Keywords
