881375-00-4
881375-00-4
Chemical Structure
KU-0060648
- CAS No.: 881375-00-4
- Formula:C33H34N4O4S
- Molecular Weight:582.71
IUPAC Name: 2-(4-ethylpiperazin-1-yl)-N-(4-(2-morpholino-4-oxo-4H-chromen-8-yl)dibenzo[b,d]thiophen-1-yl)acetamide
InChIKey: AATCBLYHOUOCTO-UHFFFAOYSA-N
SMILES: O=C(NC1=C(C2=CC=CC=C2S3)C3=C(C4=C5C(C(C=C(N6CCOCC6)O5)=O)=CC=C4)C=C1)CN7CCN(CC)CC7
Biological Activity: KU-0060648 is a dual inhibitor of PI3K and DNA-PK with IC50s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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KU-0060648 | 99.87% | KU-0060648 is a dual inhibitor of PI3K and DNA-PK with IC50s of 4 nM, 0.5 nM, 0.1 nM, 0.594 nM and 8.6 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ and DNA-PK, respectively. | ||||||||||||||||||||
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Structural Analogs
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Similarity Score 0.68
HY-11006KU-57788 -
Similarity Score 0.67
HY-145427NU5455 -
Similarity Score 0.56
HY-101667LTURM34 -
Similarity Score 0.52
HY-10108ALY294002 hydrochloride -
Similarity Score 0.52
HY-10108LY294002 -
Similarity Score 0.51
HY-108606PI-828 -
Similarity Score 0.51
HY-18650KU 59403 -
Similarity Score 0.51
HY-182452U 84569 -
Similarity Score 0.49
HY-12061KU-60019 -
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