PTK7

By Targets:	ADC Antibody (1) Akt (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (1) Bcl-2 Family (1) EGFR (1) Microtubule/Tubulin (1) PERK (1) RET (1) ROR (1) Small Interfering RNA (siRNA) (3) Wnt (2) β-catenin (3)
By Research Areas:	Cancer (10)
Oligonucleotides:	Aptamers (3) Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Targets Recommended: FAK BRK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P99829

Cofetuzumab pelidotin PF-06647020; ABBV-647; h6M24-vc0101	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cofetuzumab pelidotin (PF-06647020) is a *PTK7*-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC₅₀ of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .

HY-P99828

Cofetuzumab PF-06523435; hu24	ADC Antibody RET PERK ROR	Cancer
Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting *PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK7* expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer .

HY-160488

PTK7/β-catenin-IN-1	β-catenin	Cancer
PTK7/β-catenin-IN-1 (compound 01065) is a potent *PTK7/β-catenin* inhibitor with an IC₅₀ of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research .

HY-RS17543

Ptk7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk7 Mouse Pre-designed siRNA Set A Ptk7 Mouse Pre-designed siRNA Set A

HY-RS11404

PTK7 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PTK7 Human Pre-designed siRNA Set A contains three designed siRNAs for PTK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PTK7 Human Pre-designed siRNA Set A PTK7 Human Pre-designed siRNA Set A

HY-RS24001

Ptk7 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ptk7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ptk7 Rat Pre-designed siRNA Set A Ptk7 Rat Pre-designed siRNA Set A

HY-160493

PTK7/β-catenin-IN-6	Wnt β-catenin	Cancer
PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) .

HY-160489

PTK7/β-catenin-IN-2	β-catenin Wnt	Cancer
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of *PTK7/β-catenin*. It inhibits the binding of PTK7 to β-catenin (IC₅₀: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC₅₀ of 157.1 μM .

HY-182914

NGI-189	EGFR Akt Bcl-2 Family Apoptosis	Cancer
NGI‑189 is a selective OST‑A inhibitor. NGI‑189 inhibits the STT3A catalytic subunit of the OST complex and reduces N‑glycosylation of target glycoproteins. NGI‑189 blocks oncogenic and bypass signaling, reduces phosphorylation of EGFR, AKT, p70S6K and S6RP, and induces cell cycle arrest and apoptosis. NGI‑189 markedly suppresses tumor growth and induces tumor regression in non‑small cell lung cancer (NSCLC) xenograft models. NGI‑189 can be used for the research of EGFR‑mutant non‑small cell lung cancer .

Cat. No.	Product Name	Type

HY-160065F

FAM-sgc8c aptamer sodium	Fluorescent Dyes
FAM-sgc8c aptamer sodium is a 5-FAM labeled sgc8c aptamer sodium (HY-160065). sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase *PTK-7, which is mainly expressed on cervical cancer HeLa cells. Binding of FAM-sgc8c aptamer sodium to PTK-7* induces the assembly of nanotags on the cell surface, resulting in strong fluorescence and SERS signals .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99829

Cofetuzumab pelidotin PF-06647020; ABBV-647; h6M24-vc0101	Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin	Cancer
Cofetuzumab pelidotin (PF-06647020) is a *PTK7*-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC₅₀ of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .

HY-P99828

Cofetuzumab PF-06523435; hu24	ADC Antibody RET PERK ROR	Cancer
Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting *PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK7* expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer .

Species:	Human (5) Rhesus Macaque (1) Rat (2) Mouse (3) Cynomolgus (1) Rabbit (1)
Tag:	His (8) Avi (3) Fc (4)
Source:	HEK293 (11) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P78398

	PTK7 Protein, Human (HEK293, His) CCK-4; PTK7	Human	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (HEK293, His-Avi) is the recombinant human-derived PTK7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P703967

	PTK7 Protein, Human (HEK293, hFc) CCK-4; PTK7	Human	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (HEK293, hFc) is the recombinant human-derived PTK7 protein, expressed by HEK293, with C-hFc labeled tag.

HY-P703966

	PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi) CCK-4; PTK7	Mouse	HEK293
	Ptk7 Protein is a cell surface receptor that plays a crucial role in regulating cell migration and tissue development. Dysregulation of Ptk7 Protein has been associated with various diseases, including cancer and developmental disorders. Targeting Ptk7 Protein may offer potential therapeutic interventions in these conditions by modulating cell migration, inhibiting tumor growth, and promoting normal tissue development. PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi) is the recombinant mouse-derived PTK7 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

HY-P705077

	PTK7 Protein, Human (Biotinylated, HEK293, Fc-Avi) CCK-4; PTK7	Human	HEK293

HY-P703970

	PTK7 Protein, Human (Biotinylated, HEK293, His, Avi) CCK-4; PTK7	Human	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived PTK7 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

HY-P78619

	PTK7 Protein, Rat (HEK293, His) 1 Publications Verification PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Rat	HEK293
	The PTK7 protein is predicted to mediate cell adhesion molecule binding and play critical roles in a variety of cellular processes, including actin cytoskeleton reorganization and regulation of the canonical Wnt signaling pathway. It affects animal organ development, axis elongation, and epithelial morphogenesis. PTK7 Protein, Rat (HEK293, His) is the recombinant rat-derived PTK7 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78761

	PTK7 Protein, Mouse (HEK293, His) 1 Publications Verification PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Mouse	HEK293
	Ptk7 Protein is a cell surface receptor that plays a crucial role in regulating cell migration and tissue development. Dysregulation of Ptk7 Protein has been associated with various diseases, including cancer and developmental disorders. Targeting Ptk7 Protein may offer potential therapeutic interventions in these conditions by modulating cell migration, inhibiting tumor growth, and promoting normal tissue development. PTK7 Protein, Mouse (HEK293, His) is the recombinant mouse-derived PTK7 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78603

	PTK7 Protein, Rabbit (HEK293, His) PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Rabbit	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived PTK7 protein, expressed by HEK293 , with C-10*His labeled tag.

HY-P78618

	PTK7 Protein, Rat (HEK293, Fc) PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Rat	HEK293
	The PTK7 protein is predicted to mediate cell adhesion molecule binding and play critical roles in a variety of cellular processes, including actin cytoskeleton reorganization and regulation of the canonical Wnt signaling pathway. It affects animal organ development, axis elongation, and epithelial morphogenesis. PTK7 Protein, Rat (HEK293, Fc) is the recombinant rat-derived PTK7 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P704963

	PTK7 Protein, Mouse (HEK293, Fc) PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Mouse	HEK293

HY-P78573

	PTK7 Protein, Cynomolgus/Rhesus macaque (HEK293, His) PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7	Cynomolgus;Rhesus Macaque	HEK293
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Cynomolgus/Rhesus macaque (HEK293, His) is the recombinant cynomolgus, Rhesus Macaque-derived PTK7 protein, expressed by HEK293 , with C-His labeled tag.

HY-P71821

	PTK7 Protein, Human (P.pastoris, His) CCK 4; CCK-4; Colon carcinoma kinase 4; Inactive tyrosine-protein kinase 7; Tyrosine-protein kinase-like 7	Human	P. pastoris
	The PTK7 protein is an inactive tyrosine kinase that plays a key role in both non-canonical and canonical Wnt signaling pathways. Effects include cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. PTK7 Protein, Human (P.pastoris, His) is the recombinant human-derived PTK7 protein, expressed by P. pastoris , with N-6*His labeled tag.

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Host:	Mouse (3)
Reactivity:	Human (3)
Application:	IHC-P (3) ICC/IF (1) WB (3) ELISA (3)
Isotype:	IgG1 (2)
Conjugation:	Non-conjugated (3) Biotin (3)
Clonality:	Monoclonal (2)
Modification:	Unmodified (2)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84534

	CCK-4 Antibody (YA4231) CCK4; PTK7	WB, IHC-P, ELISA	Human
	CCK-4 Antibody (YA4231) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCK-4.

HY-P84534A

	CCK-4 Antibody (YA4231)(PBS only) CCK4; PTK7	WB, IHC-P, ELISA	Human
	CCK-4 Antibody (YA4231) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CCK-4.

HY-P85079

	CCK-4 Antibody (YA4771) PTK7; CCK4; Inactive tyrosine-protein kinase 7; Colon carcinoma kinase 4; CCK-4; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7	WB, IHC-P, ICC/IF, ELISA	Human
	CCK-4 Antibody (YA4771) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to CCK-4.

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Cat. No.	Product Name		Classification

HY-RS17543

Ptk7 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ptk7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS11404

PTK7 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
PTK7 Human Pre-designed siRNA Set A contains three designed siRNAs for PTK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24001

Ptk7 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ptk7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-177571

Sgc8c-M Sgc8c-VcMMAE		Aptamers
Sgc8c-M is a *PTK7*-targeted aptamer-drug conjugate (ApDC). Sgc8c-M is composed of the classic *PTK7*-specific aptamer Sgc8c, a cathepsin B (CTSB)-cleavable valine-citrulline (VC)-based linker, and the potent antimitotic agent Monomethyl auristatin E (MMAE) (HY-15162) as the payload. Sgc8c-M inhibits the growth of PTK7-overexpressing cancer cells. Sgc8c-M can be used for the study of PTK7-expressing advanced solid tumors .

HY-160065

sgc8c aptamer sodium		Aptamers
sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase *PTK-7, which is mainly expressed on cervical cancer HeLa cells. sgc8c aptamer sodium can precisely bring the nanotags connected to it to the surface of cells expressing PTK-7*, thus achieving specific recognition and labeling of target cells .

HY-177870

Sgc8c Aptamer		Aptamers
Sgc8c Aptamer is a single-stranded DNA aptamer targeting protein tyrosine kinase 7 (PTK7) with K_d of 1.03-11.73 nM for human, mice, rat and monkey. Sgc8c Aptamer can be used to synthesize aptamer-drug conjugates and can be used for cancer research .

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