28 Results for "

PTK7

" in MedChemExpress (MCE) Product Catalog:
Products (28)

28 Results for "PTK7" in MCE Product Catalog:

  • Targets Recommended:
1
1 Cited Publications
Cat. No.: HY-P78619
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7
Species:  
Rat
Source:  
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1
1 Cited Publications
Cat. No.: HY-P78761
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7
Species:  
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Cat. No.: HY-P99829
CAS No.: 1869937-48-3
Synonyms: PF-06647020; ABBV-647; h6M24-vc0101
Cofetuzumab pelidotin (PF-06647020) is a PTK7-targeting ADC comprising a humanized anti-PTK7 mAb (hu6M024, IgG1) joined to an auristatin microtubule inhibitor payload, auristatin-0101 (Aur0101; HY-12522), by a cleavable valine-citrulline (vc)-based linker. Cofetuzumab pelidotin has a DAR of 4. Cofetuzumab pelidotin binds to cell-surface PTK7 with an EC50 of 1153 pM by flow cytometry. Cofetuzumab pelidotin has the potential for solid tumors research .
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Cat. No.: HY-P99828
CAS No.: 1869928-62-0
Synonyms: PF-06523435; hu24

Target:  

ADC Antibodies RET PERK ROR

Research Areas:  

Cancer

Cofetuzumab (PF-06523435) is a humanized IgG1-κ monoclonal antibody targeting PTK7. The expression system of Cofetuzumab is typically CHO (Chinese hamster ovary) cells. Cofetuzumab downregulates PTK7 expression, modulates its downstream signaling pathways, and inhibits tumor sphere formation of ovarian cancer cells. Cofetuzumab can be used to synthesize the ADC molecule Cofetuzumab pelidotin (HY-P99829). Cofetuzumab is applicable to the research of tumors such as ovarian cancer .
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Cat. No.: HY-160488
CAS No.: 906147-24-8
Target:  

β-catenin

Research Areas:  

Cancer

PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research .
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Cat. No.: HY-RS11404
Research Areas:  

Others

PTK7 Human Pre-designed siRNA Set A contains three designed siRNAs for PTK7 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS17543
Research Areas:  

Others

Ptk7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ptk7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS24001
Research Areas:  

Others

Ptk7 Rat Pre-designed siRNA Set A contains three designed siRNAs for Ptk7 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Sgc8c-M
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Sgc8c-M
Cat. No.: HY-177571
Synonyms: Sgc8c-VcMMAE
Sgc8c-M is a PTK7-targeted aptamer-drug conjugate (ApDC). Sgc8c-M is composed of the classic PTK7-specific aptamer Sgc8c, a cathepsin B (CTSB)-cleavable valine-citrulline (VC)-based linker, and the potent antimitotic agent Monomethyl auristatin E (MMAE) (HY-15162) as the payload. Sgc8c-M inhibits the growth of PTK7-overexpressing cancer cells. Sgc8c-M can be used for the study of PTK7-expressing advanced solid tumors .
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Cat. No.: HY-160493
CAS No.: 1219439-82-3
Target:  

Wnt β-catenin

Research Areas:  

Cancer

PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC) .
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sgc8c aptamer sodium
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DNA, 5'-ATCTAACTGCTGCGCCGCCGGGAAAATACTGTACGGTTAGA-3', sodium salt
Cat. No.: HY-160065
sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. sgc8c aptamer sodium can precisely bring the nanotags connected to it to the surface of cells expressing PTK-7, thus achieving specific recognition and labeling of target cells .
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Cat. No.: HY-160489
CAS No.: 902434-29-1
Target:  

β-catenin Wnt

Research Areas:  

Cancer

PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM .
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Cat. No.: HY-160065F
FAM-sgc8c aptamer sodium is a 5-FAM labeled sgc8c aptamer sodium (HY-160065). sgc8c aptamer sodium is an aptamer that specifically targets the human protein tyrosine kinase PTK-7, which is mainly expressed on cervical cancer HeLa cells. Binding of FAM-sgc8c aptamer sodium to PTK-7 induces the assembly of nanotags on the cell surface, resulting in strong fluorescence and SERS signals .
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Cat. No.: HY-P78398
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CCK-4; PTK7
Species:  
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Cat. No.: HY-P703967
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CCK-4; PTK7
Species:  
Source:  
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Cat. No.: HY-P703966
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CCK-4; PTK7
Species:  
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Cat. No.: HY-P705077
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CCK-4; PTK7
Species:  
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Cat. No.: HY-P703970
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: CCK-4; PTK7
Species:  
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Cat. No.: HY-P78603
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7
Species:  
Source:  
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Cat. No.: HY-P78618
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PTK7; CCK4; CCK-4; Tyrosine-protein kinase-like 7; Protein-tyrosine kinase 7; Protein-tyrosine kinase 7
Species:  
Rat
Source:  
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