2. Stem Cell/Wnt
  3. Wnt β-catenin
  4. PTK7/β-catenin-IN-6

PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC).

For research use only. We do not sell to patients.

PTK7/β-catenin-IN-6 Chemical Structure

PTK7/β-catenin-IN-6 Chemical Structure

CAS No. : 1219439-82-3

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5 mg USD 783 In-stock
10 mg USD 1410 In-stock
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Based on 1 publication(s) in Google Scholar

PTK7/β-catenin-IN-6 Related Antibodies

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Description

PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC)[1].

In Vitro

PTK7/β-catenin-IN-6 (25 μM) misregulates the β-catenin responsive transcription and inihibits the Wnt signaling pathway through regulating the mRNA expressions of Wnt signaling related genes, which are associated with cell proliferation and migration[1].
PTK7/β-catenin-IN-6 (0-100 μM) arrests the cell cycle in G0/G1 phase through block of CyclinA2, CyclinE2 and CDK production, inhibits proliferations of HCT116, SW480 and MEF with IC50s of 20.1, 19.6 and 46.3 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTK7/β-catenin-IN-6 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HCT116, SW480 and MEF
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Inhibited proliferations of cells HCT116, SW480 and MEF.

Western Blot Analysis[1]

Cell Line: HCT116, SW480
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Decreased levels of CyclinA2, CyclinE2 and CDK.

RT-PCR[1]

Cell Line: HCT116, SW480
Concentration: 25 μM
Incubation Time: 24 h
Result: Increased mRNA levels of PLAUR, FOSL1 and NRP1.
Decreased mRNA levels of AXIN2.
Molecular Weight

480.34

Formula

C25H19Cl2N3O3
CAS No.
Appearance

Solid

SMILES

O=C(N1C2=C(NC(C1CC(NC3=CC=C(C(Cl)=C3)Cl)=O)=O)C=CC=C2)/C=C/C4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 73.33 mg/mL (152.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0819 mL 10.4093 mL 20.8186 mL
5 mM 0.4164 mL 2.0819 mL 4.1637 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0819 mL 10.4093 mL 20.8186 mL 52.0465 mL
5 mM 0.4164 mL 2.0819 mL 4.1637 mL 10.4093 mL
10 mM 0.2082 mL 1.0409 mL 2.0819 mL 5.2046 mL
15 mM 0.1388 mL 0.6940 mL 1.3879 mL 3.4698 mL
20 mM 0.1041 mL 0.5205 mL 1.0409 mL 2.6023 mL
25 mM 0.0833 mL 0.4164 mL 0.8327 mL 2.0819 mL
30 mM 0.0694 mL 0.3470 mL 0.6940 mL 1.7349 mL
40 mM 0.0520 mL 0.2602 mL 0.5205 mL 1.3012 mL
50 mM 0.0416 mL 0.2082 mL 0.4164 mL 1.0409 mL
60 mM 0.0347 mL 0.1735 mL 0.3470 mL 0.8674 mL
80 mM 0.0260 mL 0.1301 mL 0.2602 mL 0.6506 mL
100 mM 0.0208 mL 0.1041 mL 0.2082 mL 0.5205 mL
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PTK7/β-catenin-IN-6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTK7/β-catenin-IN-61219439-82-3Wntβ-cateninBeta catenintyrosine kinase receptorPTK7HCT116SW480MEFCRCcolorectal cancerInhibitorinhibitorinhibit

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