2. Stem Cell/Wnt
  3. β-catenin
  4. PTK7/β-catenin-IN-1

PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research.

For research use only. We do not sell to patients.

PTK7/β-catenin-IN-1 Chemical Structure

PTK7/β-catenin-IN-1 Chemical Structure

CAS No. : 906147-24-8

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PTK7/β-catenin-IN-1 Related Antibodies

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Description

PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research[1].

In Vitro

PTK7/β-catenin-IN-1 (compound 01065; 72 h) has antiproliferative properties in HCT116, SW480 and MEFs with IC50s of 19.6 µM, 21.3 µM, 41 µM, respectively[1].
PTK7/β-catenin-IN-1 (25 µM; 24 h) increased the percentage of HCT116 and SW480 cells in S phase with subsequent decrease in G0/G1 phases suggesting S phase arrest that inhibits cell cycle progression[1].
PTK7/β-catenin-IN-1 (25 µM; 24 h) causes a significant increase in p21 and p27 protein levels[1].
PTK7/β-catenin-IN-1 (25 µM; 24 h) causes significant reduction in AXIN2 mRNA level in HCT116 and SW480[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PTK7/β-catenin-IN-1 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HCT116 and SW480 cells
Concentration: 25 µM
Incubation Time: 24 h
Result: Induced an obvious cell cycle arrest through distinct mechanisms.
Increased the percentage of HCT116 and SW480 cells in S phase with subsequent decrease in G0/G1 phases suggesting S phase arrest that inhibits cell cycle progression.

Western Blot Analysis[1]

Cell Line: HCT116 and SW480 cells
Concentration: 25 µM
Incubation Time: 24 h
Result: Caused a significant increase in p21 and p27 protein levels.

RT-PCR[1]

Cell Line: HCT116 and SW480 cells
Concentration: 25 µM
Incubation Time: 24 h
Result: Caused a significant reduction in AXIN2 mRNA leve.
Molecular Weight

340.37

Formula

C22H16N2O2
CAS No.
Appearance

Solid

SMILES

O=C(C(C1=CNC2=C1C=CC=C2)=O)NC3=C(C4=CC=CC=C4)C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (176.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9380 mL 14.6899 mL 29.3798 mL
5 mM 0.5876 mL 2.9380 mL 5.8760 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9380 mL 14.6899 mL 29.3798 mL 73.4495 mL
5 mM 0.5876 mL 2.9380 mL 5.8760 mL 14.6899 mL
10 mM 0.2938 mL 1.4690 mL 2.9380 mL 7.3449 mL
15 mM 0.1959 mL 0.9793 mL 1.9587 mL 4.8966 mL
20 mM 0.1469 mL 0.7345 mL 1.4690 mL 3.6725 mL
25 mM 0.1175 mL 0.5876 mL 1.1752 mL 2.9380 mL
30 mM 0.0979 mL 0.4897 mL 0.9793 mL 2.4483 mL
40 mM 0.0734 mL 0.3672 mL 0.7345 mL 1.8362 mL
50 mM 0.0588 mL 0.2938 mL 0.5876 mL 1.4690 mL
60 mM 0.0490 mL 0.2448 mL 0.4897 mL 1.2242 mL
80 mM 0.0367 mL 0.1836 mL 0.3672 mL 0.9181 mL
100 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7345 mL
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PTK7/β-catenin-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PTK7/β-catenin-IN-1906147-24-8β-cateninBeta cateninPTK7p53/MDM2cancerHCT116SW480Inhibitorinhibitorinhibit

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