PTK7/β-catenin-IN-2
Based on 1 Customer Validation
PTK7/β-catenin-IN-2 (compound 04967) is an inhibitor of PTK7/β-catenin. It inhibits the binding of PTK7 to β-catenin (IC50: 5.6 μM), thereby inhibiting the signaling of the Wnt/β-catenin pathway. PTK7/β-catenin-IN-2 targets cell growth dependent on the Wnt signaling pathway and has anticancer properties. PTK7/β-catenin-IN-2 also showed inhibitory potency against p53 and MDM2 binding with an IC50 of 157.1 μM.
For research use only. We do not sell to patients.
- Purity: 96.96%
- CAS No.: 902434-29-1
- Formula: C30H34Cl2N6O
- Molecular Weight:565.54
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IC50: 5.6 μM (Interaction between PTK7 and β-catenin)[1]; 157.1 μM (Interaction between p53 and MDM2)[1]
Chemical Information
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CAS No. 902434-29-1
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Appearance Solid
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Molecular Weight 565.54
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Formula C30H34Cl2N6O
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Color White to off-white
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SMILES
O=C(CCC1=C(C)N2N=C(C3=CC=C(Cl)C=C3)C=C2N=C1C)NCCCN4CCN(CC4)C5=CC(Cl)=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMF : 25 mg/mL (44.21 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 1.7682 mL | 8.8411 mL | 17.6822 mL | 44.2055 mL |
| 5 mM | 0.3536 mL | 1.7682 mL | 3.5364 mL | 8.8411 mL | |
| 10 mM | 0.1768 mL | 0.8841 mL | 1.7682 mL | 4.4206 mL | |
| 15 mM | 0.1179 mL | 0.5894 mL | 1.1788 mL | 2.9470 mL | |
| 20 mM | 0.0884 mL | 0.4421 mL | 0.8841 mL | 2.2103 mL | |
| 25 mM | 0.0707 mL | 0.3536 mL | 0.7073 mL | 1.7682 mL | |
| 30 mM | 0.0589 mL | 0.2947 mL | 0.5894 mL | 1.4735 mL | |
| 40 mM | 0.0442 mL | 0.2210 mL | 0.4421 mL | 1.1051 mL |
PTK7/β-catenin-IN-2 Related Classifications
HY-160489 Related Classifications
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