2. Protéines recombinantes
  3. Receptor Proteins Biotinylated Proteins
  4. PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi)

PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi)

Cat. No.: HY-P703966
Instruction de manipulation Technical Support

Ptk7 Protein is a cell surface receptor that plays a crucial role in regulating cell migration and tissue development. Dysregulation of Ptk7 Protein has been associated with various diseases, including cancer and developmental disorders. Targeting Ptk7 Protein may offer potential therapeutic interventions in these conditions by modulating cell migration, inhibiting tumor growth, and promoting normal tissue development. PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi) is the recombinant mouse-derived PTK7 protein, expressed by HEK293, with C-Avi and C-His labeled tag.

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Description

Ptk7 Protein is a cell surface receptor that plays a crucial role in regulating cell migration and tissue development. Dysregulation of Ptk7 Protein has been associated with various diseases, including cancer and developmental disorders. Targeting Ptk7 Protein may offer potential therapeutic interventions in these conditions by modulating cell migration, inhibiting tumor growth, and promoting normal tissue development. PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi) is the recombinant mouse-derived PTK7 protein, expressed by HEK293, with C-Avi and C-His labeled tag.
Background

Ptk7 Protein is an inactive tyrosine kinase that plays a crucial role in the Wnt signaling pathway, specifically in both the non-canonical (Wnt/planar cell polarity signaling) and canonical Wnt signaling pathways. It is involved in various cellular processes, including cell adhesion, migration, polarity, proliferation, actin cytoskeleton reorganization, and apoptosis. Ptk7 Protein also contributes to embryogenesis, epithelial tissue organization, and angiogenesis. Additionally, it interacts with CTNNB1, further highlighting its significance in Wnt signaling.
Species

Mouse
Source

HEK293
Tag

C-Avi;C-8*His
Accession

Q8BKG3 (A23-T696)
Gene ID

71461
Molecular Construction
N-term
PTK7 (A23-T696)
Accession # Q8BKG3
8*His-Avi
C-term
Protein Length

Extracellular Domain
Conjugation

Biotin
Synonyms
CCK-4; PTK7
AA Sequence

AIVFIKEPSSQDALQGRRALLRCEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDSGAFQCVARDNVTGEEVRSTNASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSVADESFARVVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANGSLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEPRVFIAGDEERVTCPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELVFVTIAESDTGVYTCHASNLAGQRRQDVNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSKNGTLRINSVEVYDGTLYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPVMEDSEGPGSPPPYKMIQT

Predicted Molecular Mass
77.5 kDa
Masse moléculaire

Approximately 90-110 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.
Pureté

≥ 95%, as determined by Bis-Tris PAGE.
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Instruction de manipulation (2659 KB)

PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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PTK7 Protein, Mouse (Biotinylated, HEK293, His, Avi)
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