3 Results for "

Progerin

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Progerin" in MCE Product Catalog:

Trifluoroacetyl tripeptide-2
Trifluoroacetyl tripeptide-2
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Cat. No.: HY-P5238
CAS No.: 64577-63-5
Target:  

Peptides

Research Areas:  

Others

Trifluoroacetyl tripeptide-2 is a tripeptide with strong cosmetic activity. Trifluoroacetyl tripeptide-2 can regulate progerin synthesis, promote extracellular matrix synthesis, and improve skin elasticity. Trifluoroacetyl tripeptide-2 has anti-wrinkle and firming effects and can be used as an anti-aging ingredient in cosmetic research .
Progerinin
Progerinin
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Cat. No.: HY-159834
CAS No.: 2249696-72-6
Synonyms: SLC-D011
Target:  

DNA/RNA Synthesis

Research Areas:  

Others

Progerinin (SLC-D011) is an orally active progerin-lamin A binding inhibitor. Progerinin selectively binds to the C-terminal region of progerin, disrupting its interaction with lamin A and promoting progerin degradation while sparing wild-type lamin A, B, and C. Progerinin ameliorates nuclear deformation, increases H3K9me3 levels, and reduces progerin expression in HGPS patient-derived fibroblasts. Progerinin extends lifespan in Lmna G609G/G609G mice and Lmna G609G/+ mice, improves body weight, hair morphology, cardiac function, and histological phenotypes. Progerinin can be used for the study of Hutchinson-Gilford progeria syndrome (HGPS) .
UCM-13207
UCM-13207
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Cat. No.: HY-149708
CAS No.: 1621536-10-4
Purity:  99.61%
Target:  

ICMT

Research Areas:  

Others

UCM-13207 is a selective isoprenylcysteine carboxylmethyltransferase (ICMT) inhibitor with a human IC50 of 1.4 μM and human Ka of 7.2 μM. UCM-13207 modulates progerin localization, stability, and levels, reduces DNA damage, increases cellular viability, and decreases tissue senescence. UCM-13207 can be used for the research of Hutchinson−Gilford progeria syndrome .
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