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S. mansoni

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By Targets:	Antibiotic (2) Apoptosis (1) Bacterial (3) Cathepsin (1) Endogenous Metabolite (1) Glycosidase (1) Legumain (1) Parasite (15) Reference Standards (2) Sirtuin (1)
By Research Areas:	Infection (17) Neurological Disease (4)

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Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W004260

Arachidic acid 3 Publications Verification Eicosanoic acid	Endogenous Metabolite	Neurological Disease
Arachidic acid is an orally bioavailable membrane fluidity modulator and receptor/ion channel effector. Arachidic acid does not activate arachidonic acid-sensitive K ⁺ channels in rat midbrain and hypothalamic neurons. Arachidic acid alleviates age-related spatial cognitive impairment. Arachidic acid is applicable for research related to age-related spatial cognitive impairment .

HY-17035

Doramectin 5 Publications Verification	Parasite Antibiotic Bacterial	Infection
Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model .

HY-112205A

RR-11a analog Maximum Cited Publications 8 Publications Verification	Parasite Legumain	Infection
RR-11a analog is a potent and irreversible inhibitor of *Schistosoma mansoni* legumain, with an IC₅₀** of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor .

HY-101725

Meclonazepam Ro 11-3128; Ro 11-3128/002	Parasite	Infection Neurological Disease
Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect . Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect .

HY-N4184

Licoflavone B	Parasite	Infection
Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC₅₀, 23.78 µM) and ADPase (IC₅₀, 31.50 µM) activity. Anti-schistosomiasis activity .

HY-17035R

Doramectin (Standard)	Reference Standards Parasite Antibiotic Bacterial	Infection
Doramectin (Standard) is the analytical standard of Doramectin. This product is intended for research and analytical applications. Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model .

HY-161596

SmCB1-IN-1	Parasite Cathepsin	Infection
SmCB1-IN-1 (Compound 2h) is an inhibitor for S. mansoni cathepsin B1 (SmCB1) with an K_i of 0.05 μM . SmCB1-IN-1 exhibits selectivity toward human off-target cathepsins (29% and 37% inhibition for CatB and CatL at 20 μM). SmCB1-IN-1 inhibits 68% Schistosoma mansoni at 1 μM .

HY-178773

SIRT2-IN-18	Sirtuin Apoptosis	Infection
SIRT2-IN-18 (Compound 8) is a SIRT2 inhibitor with *IC₅₀s of 5.3  and 12.3 μM for SmSIRT2 and hSIRT2, respectively. SIRT2-IN-18 shows potent antischistosomal activities against both Liberian and Puerto Rican strains of Schistosoma mansoni* and reduces schistosomula and adult worm pair viability, pairing, and egg production, with low cytotoxicity in mammalian cells. SIRT2-IN-18 increases histone H3 hyperacetylation and induces cytochrome c-mediated apoptosis .

HY-169445

(±)-Meclonazepam (±)-Ro 11-3128; (±)-Ro 11-3128/002	Parasite	Infection Neurological Disease
(±)-Meclonazepam ((±)-Ro 11-3128) is the racemate of Meclonazepam (HY-101725). Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect . Meclonazepam exhibits antischistosomal activity against S. mansoni .

HY-168547S

AR89-d6	Parasite	Infection
AR89-d6 (Compound AR102) is a deuterated derivative of AR89 with oral activity. AR89-d6 demonstrates activity against S. mansoni, S. haematobium, and S. japonicum, and can be utilized for research on schistosomiasis .

HY-N7854

Anacardic acid diene Anacardic acid 15:2	Bacterial	Infection
Anacardic acid diene is a polyunsaturated form of anacardic acid (HY-N2020) that has been found in cashew nut shell liquid. It has antibacterial activity against methicillin resistant S. aureus (MRSA) and S. mutans (MICs=12.5 and 6.25 μg/mL, respectively). Anacardic acid diene has schistosomicidal activity against adult S. mansoni worms when used at a concentration of 100 μM. It also inhibits soybean lipoxygenase-1 in a time-dependent manner.

HY-101258

Cardol triene	Parasite	Infection
Cardol triene is a phenol found in cashew nut shell liquid that competitively and irreversibly inhibits mushroom tyrosinase (IC₅₀=22.5 μM). It is schistosomicidal, killing 25, 75, and 100% of S. mansoni worms after 24 hours when used at concentrations of 50, 100, or 200 μM, respectively. It has been used as a starting material for the synthesis of bis-benzoxazines.

HY-122522

2-Methylcardol triene	Glycosidase Parasite	Infection
2-Methylcardol triene is a phenol found in cashew nut shell liquid that inhibits α-glucosidase (IC₅₀=39.6 μM). 2-Methylcardol triene is schistosomicidal, killing 100% of adult S. mansoni worms after 24 hours when used at concentrations of 100 and 200 μM. 2-Methylcardol triene has been used as a starting material for the synthesis of mono- and bis-benzoxazines.

HY-180352

Antiparasitic agent-37	Parasite	Infection
Antiparasitic agent-37 (Compound 4717) is an orally active antiparasitic agent. Antiparasitic agent-37 exhibits activity against S. mansoni in mice. Antiparasitic agent-37 has an oral LD₅₀ of 0.4 g/kg in mice after a single dose. Antiparasitic agent-37 can be used for the research of infectious diseases .

HY-101725R

Meclonazepam (Standard) Ro 11-3128 (Standard); Ro 11-3128/002 (Standard)	Reference Standards Parasite	Infection Neurological Disease
Meclonazepam (Standard) (Ro 11-3128 (Standard)) is the analytical standard of Meclonazepam (HY-101725). This product is intended for research and analytical applications. Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect . Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect .

HY-180337

Antiparasitic agent-38	Parasite	Infection
Antiparasitic agent-38 is an orally active antischistosomal agent that effectively clears Schistosoma mansoni infections in mice (single oral LD₅₀=0.8 g/kg) and significantly inhibits S. mansoni infection. Antiparasitic agent-38 can be used for research on schistosomiasis, particularly S. mansoni infection .

HY-180360

Antiparasitic agent-34	Parasite	Infection
Antiparasitic agent-34 (Compound NO.6913) is an orally active antiparasitic agent. Antiparasitic agent-34 exhibits anti-S. mansoni activity in mice .

HY-179116

BL-1005 BS2463	Parasite	Infection
BL-1005 (BS2463), thiophen-2-yl pyrimidine (TTP), is a potent paralytic of Schistosoma mansoni with an EC₅₀ of 37 nM. BL-1005 shows low cytotoxicity for HEK293, HeLa and HepG2 cell with CC₅₀ >20 μM. BL-1005 can induce paralysis in both adult and juvenile S. mansoni. BL-1005 can be used for the research of infection .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W004260

Arachidic acid 3 Publications Verification Eicosanoic acid	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Arachidic acid is an orally bioavailable membrane fluidity modulator and receptor/ion channel effector. Arachidic acid does not activate arachidonic acid-sensitive K ⁺ channels in rat midbrain and hypothalamic neurons. Arachidic acid alleviates age-related spatial cognitive impairment. Arachidic acid is applicable for research related to age-related spatial cognitive impairment .

HY-17035

Doramectin 5 Publications Verification	Infection Microorganisms Antibiotics Anti-parasitic Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Parasite Antibiotic Bacterial
Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model .

HY-N4184

Licoflavone B	Infection Flavonoids Classification of Application Fields Flavones Leguminosae Glycyrrhiza inflata Batal. Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Parasite
Licoflavone B is a flavonoid isolated from Glycyrrhiza inflata, inhibits S. mansoni ATPase (IC₅₀, 23.78 µM) and ADPase (IC₅₀, 31.50 µM) activity. Anti-schistosomiasis activity .

HY-17035R

Doramectin (Standard)	Structural Classification Microorganisms Antibiotics Anti-parasitic Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Parasite Antibiotic Bacterial
Doramectin (Standard) is the analytical standard of Doramectin. This product is intended for research and analytical applications. Doramectin is a derivative of Ivermectin (HY-15310). Doramectin is a potent antiparasitic antibiotic. Doramectin is an active compound against S.mansoni in an NMRI mouse infection model .

Cat. No.	Product Name	Chemical Structure

HY-168547S

AR89-d6
AR89-d6 (Compound AR102) is a deuterated derivative of AR89 with oral activity. AR89-d6 demonstrates activity against S. mansoni, S. haematobium, and S. japonicum, and can be utilized for research on schistosomiasis .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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S. mansoni

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products