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Results for "

Schisandra

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (3) AMPK (2) Apoptosis (5) Autophagy (7) Bcl-2 Family (1) CaMK (1) Caspase (1) CD74 (1) CDK (1) COX (1) Cyclin G-associated Kinase (GAK) (1) Cytochrome P450 (2) Drug Derivative (7) ERK (2) Ferroptosis (1) Glutathione S-transferase (1) Glycosidase (1) GSK-3 (3) HBV (3) HCV (1) HIV (8) HSP (1) IKK (1) Influenza Virus (1) Interleukin Related (4) JNK (1) Keap1-Nrf2 (2) Microtubule/Tubulin (1) mTOR (3) NF-κB (2) NO Synthase (3) P-glycoprotein (1) p38 MAPK (2) PARP (2) PERK (1) PI3K (3) Platelet-activating Factor Receptor (PAFR) (1) PPAR (1) Reactive Oxygen Species (ROS) (6) Reference Standards (4) Reverse Transcriptase (1) Tau Protein (2) TNF Receptor (3) Tyrosinase (1)
By Research Areas:	Cancer (14) Cardiovascular Disease (3) Endocrinology (1) Infection (11) Inflammation/Immunology (16) Metabolic Disease (4) Neurological Disease (10)

By Targets:

Akt (3)

AMPK (2)

Apoptosis (5)

Autophagy (7)

Bcl-2 Family (1)

CaMK (1)

Caspase (1)

CD74 (1)

CDK (1)

COX (1)

Cyclin G-associated Kinase (GAK) (1)

Cytochrome P450 (2)

Drug Derivative (7)

ERK (2)

Ferroptosis (1)

Glutathione S-transferase (1)

Glycosidase (1)

GSK-3 (3)

HBV (3)

HCV (1)

HIV (8)

HSP (1)

IKK (1)

Influenza Virus (1)

Interleukin Related (4)

JNK (1)

Keap1-Nrf2 (2)

Microtubule/Tubulin (1)

mTOR (3)

NF-κB (2)

NO Synthase (3)

P-glycoprotein (1)

p38 MAPK (2)

PARP (2)

PERK (1)

PI3K (3)

Platelet-activating Factor Receptor (PAFR) (1)

PPAR (1)

Reactive Oxygen Species (ROS) (6)

Reference Standards (4)

Reverse Transcriptase (1)

Tau Protein (2)

TNF Receptor (3)

Tyrosinase (1)

By Research Areas:

Cancer (14)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (11)

Inflammation/Immunology (16)

Metabolic Disease (4)

Neurological Disease (10)

Inhibitors & Agonists

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0089

Schisandrin B Maximum Cited Publications 11 Publications Verification γ-Schisandrin; Wuweizisu B	Autophagy Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

HY-B0766

Bicyclol SY801	Autophagy Apoptosis HBV HCV HSP Reactive Oxygen Species (ROS) Bcl-2 Family Glutathione S-transferase p38 MAPK NF-κB Microtubule/Tubulin ERK JNK TNF Receptor Interleukin Related CDK Cyclin G-associated Kinase (GAK) mTOR P-glycoprotein Ferroptosis	Infection Inflammation/Immunology Cancer
Bicyclol (SY801) is an orally active derivative of the traditional Chinese medicine Schisandra chinensis, which has antiviral, anti-inflammatory, immunomodulatory, antioxidant, anti-steatosis, anti-fibrotic and anti-tumor activities. Bicyclol regulates the expression of heat shock proteins and plays an anti-apoptosis role in hepatocytes. Bicyclol reduces the activation of NF-κB and the levels of inflammatory factors in hepatocytes infected with hepatitis C virus (HCV) by inhibiting the activation of the ROS-MAPK-NF-κB pathway, and prevents ferroptosis in acute liver injury. Bicyclol can change the expression of Mdr-1, GSH/GST and Bcl-2, increase the intracellular concentration of anticancer drugs, and sensitize drug-resistant cells to anticancer drugs. Bicyclol inhibits the proliferation of human malignant hepatoma cells by regulating the PI3K/AKT pathway and the Ras/Raf/MEK/ERK pathway. Bicyclol can be used in the study of chronic hepatitis, acute liver injury, nonalcoholic fatty liver disease, liver fibrosis and hepatocellular carcinoma .

HY-N0691

Schisandrin 3 Publications Verification Schizandrin; Schizandrol; Schizandrol-A	Autophagy	Inflammation/Immunology Cancer
Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-N0692

Schisandrol B 2 Publications Verification Gomisin-A; TJN-101; Wuweizi alcohol-B	Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy	Cancer
Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-N6866

Gomisin N	Apoptosis AMPK Akt PERK Keap1-Nrf2 Caspase PARP GSK-3 NO Synthase Interleukin Related	Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
Gomisin N is an orally active lignan compound. Gomisin N can be isolated from Schisandra chinensis. Gomisin N induces Apoptosis in a variety of cells. Gomisin N activates AMPK, Akt, MAPK/ERK, Nrf2, caspase-3 and PARP-1. Gomisin N inhibits GSK3β, nitric oxide (NO), and proinflammatory cytokines (IL-1β, IL-6, TNF-α). Gomisin N has anti-inflammatory, antioxidant, anti-obesity, anti-diabetic, and anti-melanogenesis activities. Gomisin N has anti-tumor activity against cervical cancer and liver cancer. Gomisin N improves Alzheimer's disease .

HY-N0695

Schisantherin B 1 Publications Verification Gomisin-B; Wuweizi ester-B; Schisantherin-B	PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis	Neurological Disease Inflammation/Immunology
Schisantherin B (Gomisin-B) is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression .

HY-N0385

Gomisin J 3 Publications Verification	NO Synthase AMPK CaMK NF-κB Keap1-Nrf2	Cardiovascular Disease Inflammation/Immunology
Gomisin J is a Schisandra chinensis-derived lignan that can inhibit multiple targets such as eNOS, AMPK (LKB1, CaMKIIβ), fetuin-A, NF-κB, Nrf2/HO-1, and can pass through the blood-brain barrier. Gomisin J increases NO bioavailability by activating eNOS, regulates lipid metabolism by activating the AMPK pathway, inhibits fetuin-A and NF-κB to exert anti-inflammatory effects, and activates Nrf2/HO-1 to enhance antioxidant capacity. Gomisin J has the activities of anti-hypertension, regulating liver lipid metabolism, and reducing cerebral ischemia-reperfusion injury, and can be used for research on hypertension, non-alcoholic fatty liver disease, cerebral ischemia-reperfusion injury, etc .

HY-N2209

Angeloylgomisin H	PPAR	Metabolic Disease
Angeloylgomisin H, as a major lignin extract of Schisandra rubriflora, has the potential to improve insulin-stimulated glucose uptake by activating PPAR-γ .

HY-N2245

Schisandrone	CD74	Cancer
Schisandrone, a 4-aryltetralone lignan, is isolated from the dried fruits of Schisandra sphenanthera . Schisandrone is an alpha-hemolysin (Hla) inhibitor that downregulates the transcript levels of hla, agrA and RNAIII. Hla is an integral virulence determinant in Staphylococcus aureus that determines pathogenicity. Schisandrone is a potent inhibitor against MRSA pneumonia .

HY-N3963

Gomisin M2 (+)-Gomisin M2	HIV	Infection Neurological Disease Inflammation/Immunology Cancer
Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra rubriflora with anti-HIV activity (EC₅₀ of 2.4 μM). Gomisin M2 exhibits anti-cancer and anti-allergic activities and has the potential for Alzheimer’s disease research .

HY-N0860

Schisantherin E Schizantherin-E	Others	Inflammation/Immunology
Schisantherin E is a natural compound isolated from the active fraction of the fruits of Schisandra sphenanthera Rehd. et Wils.

HY-N8260

Angeloylgomisin Q	Others	Neurological Disease
Angeloylgomisin Q is a new dibenzocyclooctadiene lignan from the stems of Schisandra sphaerandra . Angeloylgomisin Q has the potential for alzheimer's disease research .

HY-N2270

Chicanine 1 Publications Verification	p38 MAPK ERK IKK	Inflammation/Immunology
Chicanine is a lignan compound of Schisandra chinesis, inhibits LPS-induced phosphorylation of p38 MAPK, ERK 1/2 and IκB-α, with anti-inflammatory activity .

HY-N12046

Schineolignin B	HIV	Infection Inflammation/Immunology Cancer
Schineolignin B is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .

HY-N2222

Epigomisin O	Others	Inflammation/Immunology
Epigomisin O is isolate from the fruits of Schisandra plants .

HY-N2271

Angeloylgomisin O 1 Publications Verification	Others	Inflammation/Immunology
Angeloylgomisin O, a lignin extract of Schisandra rubriflora. Anti-inflammatory properties .

HY-N2293

Chamigrenal	Others	Others
Chamigrenal is a natural product that can be extract from the fruits of Schisandra sphenanthera .

HY-N11172

Schibitubin I	Others	Neurological Disease
Schibitubin I is a lignin. Schibitubin I has neuroprotective activity. Schibitubin I can be isolated from the fruits of Schisandra bicolor var. tuberculata .

HY-N10805

Schisanlignone C	Others	Others
Schisanlignone C is a chemical component of Schisandra viridis a. c. sm .

HY-N0089R

Schisandrin B (Standard) γ-Schisandrin (Standard); Wuweizisu B (Standard)	Reference Standards Autophagy Reactive Oxygen Species (ROS)	Neurological Disease Cancer
Schisandrin B (Standard) is the analytical standard of Schisandrin B. This product is intended for research and analytical applications. Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

HY-N12048

Schisandrathera D	Others	Others
Schisandrathera D is a lignan that can be isolated from Schisandra sphenanthera .

HY-N2267

(+)-Schisandrin B	Reactive Oxygen Species (ROS)	Inflammation/Immunology
(+)-Schisandrin B is an enantiomer of Schisandrin B. Schisandrin B is an active dibenzocyclooctadiene derivative isolated from the fruit of Schisandra chinensis, has antioxidant effect on rodent liver and heart .

HY-122935

Nigranoic acid	HIV Reverse Transcriptase	Infection
Nigranoic acid is a triterpenoid separated from Schisandra chinensis. Nigranoic acid inhibits HIV-1 reverse transcriptase. Nigranoic acid exhibits protective effects on brain through PARP/AIF signaling pathway in cerebral ischemia-reperfusion animal model .

HY-N11944

Schiarisanrin E	Others	Others
Schiarisanrin E (compound 5) is a lignan that can be isolated from Schisandra chinensis .

HY-N0859A

Schisanhenol B	PI3K Tyrosinase	Cardiovascular Disease
Schisanhenol B is one of the active ingredients of schisandra chinensis. Schisanhenol B is a tyrosinase inhibitor. Schisanhenol B has good binding activity with PIK3CG and can be used in the study of heart failure .

HY-N12790

Arisanschinin D Ananonin B	Glycosidase	Metabolic Disease
Arisanschinin D (Ananonin B) is an α-Glucosidase inhibitor and can be isolated from Schisandra arisanensis Hay .

HY-N2870

Angeloylisogomisin O Schisanwilsonin N	Others	Others
Angeloylisogomisin O is a compound isolated from the aerial parts of Schisandra propinqua var. propinqua .

HY-N11939

Kadsuralignan A	HIV	Infection
Kadsuralignan A (compound 1) is a dibenzocyclooctadiene lignan isolated from the leaves and stems of Schisandra lancifolia. Kadsuralignan A has anti-HIV activity with EC₅₀=2.23 μg/mL .

HY-N0691R

Schisandrin (Standard) Schizandrin (Standard); Schizandrol (Standard); Schizandrol-A (Standard)	Reference Standards Autophagy	Inflammation/Immunology Cancer
Schisandrin (Standard) is the analytical standard of Schisandrin. This product is intended for research and analytical applications. Schisandrin (Schizandrin), a dibenzocyclooctadiene lignan, is isolated from the fruit of Schisandra chinensis Baill. Schisandrin exhibits antioxidant, hepatoprotective, anti-cancer and anti-inflammatory activities. Schisandrin also can reverses memory impairment in rats .

HY-122969

Anwuweizonic acid	Others	Cancer
Anwuweizonic acid is a natural compound, isolated from Schisandra propinqua. Anwuweizonic acid is the putative anticancer active principle of Schisandra propinqua .

HY-N12047

Schineolignin C	HIV	Infection Inflammation/Immunology Cancer
Schineolignin C is a Lignan that can be isolated from the fruit of schisandra chinensis. schisandra chinensis has antihepatitis, antitumor, and anti-HIV-1 activities .

HY-N12425

Heteroclitin A	Others	Others
Heteroclitin A is a lignan isolated from the stems of Schisandra propinqua.

HY-N12714

Interiorin C	Others	Others
Interiorin C is the key active ingredient and key bioactivity marker in Schisandra chinensis (K. Interiorin) that is directly related to the improvement of hematopoietic function. Modern pharmacological research attributes Schisandra chinensis's blood-tonifying effects to its antioxidant and immunomodulatory activities .

HY-N11947

Schisanlignone B	Others	Others
Schisanligone B is a lignan isolated from Schisandra chinensis seeds .

HY-N11936

Rubriflorin B	Others	Others
Rubriflorin B is a lignan that can be isolated from Schisandra rubriflora .

HY-N3437

Kadsuric acid	Others	Others
Kadsuric acid is a Triterpenoids product that can be isolated from the fruits of Schisandra sphenanthera .

HY-N8622A

Heteroclitin B	Others	Others
Heteroclitin B is a saturated dibenzocyclooctene lignan isolated from the stems of Schisandra chinensis.

HY-N11971

Yunnankadsurin B	Others	Others
Yunnankadsurin B is a dibenzocyclooctene-type lignan isolated from the stems of Schisandra chinensis (Kadsura) .

HY-N7958

Gomisin F	Others	Others
Gomisin F is a Lignans product that can be isolated from the seeds of Schisandra chinensis (Turcz.) Baill. .

HY-N2266

Benzoylgomisin O	COX	Inflammation/Immunology
Benzoylgomisin O isolated from Schisandra rubriflora, has inhibitory activity against 15-LOX, COX-1 and COX-2 enzymes and anti-inflammatory activity .

HY-N15262

Schinlignan B Angeloylgomisin P	HIV HBV	Infection Metabolic Disease
Schinlignan B (Angeloylgomisin P) is a lignan with antioxidant, anti-HIV, anti-HBV activities, which is found in plants of the Schisandra genus. Schinlignan B is promising for research of antioxidant-associated diseases .

HY-N2264

Wulignan A1	Influenza Virus	Infection
Wulignan A1 is isolated from the stems of Schisandra henryi. Wulignan A1 exhibits anti-influenza virus H1N1 and H1N1-TR (a Tamiflu agent resistant virus strain) activities .

HY-N0859B

Schisanchinin D	NO Synthase	Neurological Disease
Schisanchinin D is an NO release inhibitor found in the fruits of Schisandra chinensis. Schisanchinin D can inhibit the release of nitric oxide (NO) by lipopolysaccharide (LPS)-activated microglia in primary murine BV2 microglia cells. Schisanchinin D is promising for research of neurodegenerative diseases such as Alzheimer's disease (AD) .

HY-N6048

Lancifodilactone F	HIV	Infection
Lancifodilactone F (compound 1) can be isolated from the leaves and stems of Schisandra lancifolia. Lancifodilactone F has anti-HIV activity with EC₅₀=20.69 μg/mL. Lancifodilactone F has cytotoxicity against C8166 cells (CC₅₀ >200 μg/mL) .

HY-N0692R

Schisandrol B (Standard) Gomisin-A (Standard); TJN-101 (Standard); Wuweizi alcohol-B (Standard)	Reference Standards Reactive Oxygen Species (ROS) Cytochrome P450 Autophagy	Cancer
Schisandrol B (Standard) is the analytical standard of Schisandrol B. This product is intended for research and analytical applications. Schisandrol B (Gomisin-A) is a major active constituent of Schisandra chinensis with hepato-protective effects. Schisandrol B inhibits reactive oxygen species (ROS) production. Schisandrol B inhibits the activity of P-glycoprotein and CYP3A and also has anti-inflammatory, anti-diabetic and antioxidant activities .

HY-118129

Schisandronic acid Ganwuweizic acid	PARP Apoptosis	Cancer
Schisandronic acid is a triterpenoid antioxidant and anticancer agent extracted from Schisandra chinensis, which has potent cytotoxicity against human breast cancer cells, especially MCF-7. Schisandronic acid induces apoptosis and reduces cell viability in a time-dependent manner (MCF-7, IC50=8.06 μM). Schisandronic acid can upregulate active caspase-3 expression and cleave PARP, reduce the generation of reactive oxygen species and exhibit antioxidant effects .

HY-N0695R

Schisantherin B (Standard) Gomisin-B (Standard); Wuweizi ester-B (Standard); Schisantherin-B (Standard)	Reference Standards PI3K Akt mTOR GSK-3 Tau Protein TNF Receptor Interleukin Related Apoptosis	Neurological Disease Inflammation/Immunology
Schisantherin B (Gomisin-B) (Standard) is the analytical standard of Schisantherin B. This product is intended for research and analytical applications. Schisantherin B is a lignan compound and one of the active components of Schisandra chinensis. Schisantherin B activates the PI3K/AKT signaling pathway, restores the activity of GSK3β, and reduces the hyperphosphorylation of tau protein in hippocampal and cerebral cortical tissues. Schisantherin B upregulates the level of GLT-1, decreases the expression of pro-inflammatory cytokines TNF-α/IL-1β/IL-6, upregulates the expression of IL-10, and inhibits cell apoptosis. Schisantherin B is applicable to the research of spinal cord injury, Alzheimer's disease and depression.

HY-N18107

Interiorin B	Others	Others
Interiorin B is a partially saturated dibenzocyclooctene lignan. Interiorin B can be isolated from the stems of Schisandra rubriflora .

HY-N19825

Lancifodilactone B	Others	Others
Lancifodilactone B is a nortriterpene found in the leaves and stems of Schisandra lancifolia .

HY-N18286

Propinquain H	Drug Derivative	Others
Propinquain H is a dibenzocyclooctadiene lignan. Propinquain H inhibits lymphocyte proliferation. Propinquain H can be isolated from the roots of Schisandra propinqua subsp. sinensis .

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