1. Autophagy
    Metabolic Enzyme/Protease
    Immunology/Inflammation
    NF-κB
  2. Autophagy
    Reactive Oxygen Species
  3. Schisandrin B

Schisandrin B (Synonyms: γ-Schisandrin; Wuweizisu B)

Cat. No.: HY-N0089 Purity: 99.99%
Handling Instructions

Schisandrin B (γ-Schisandrin) is a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart.

For research use only. We do not sell to patients.

Schisandrin B Chemical Structure

Schisandrin B Chemical Structure

CAS No. : 61281-37-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 479 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Schisandrin B:

Top Publications Citing Use of Products

    Schisandrin B purchased from MCE. Usage Cited in: Front Pharmacol. 31 July 2020

    BMMs are cultured with or without 20 μM Schisandrin B in the presence of M-CSF and RANKL for the indicated time periods. The inhibitory effects of Schisandrin B on osteoclast-related genes expression are further confirmed by Western blot analysis, which shows that Schisandrin B dramatically suppresses the protein expression of these target genes during osteoclast differentiation.
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    Description

    Schisandrin B (γ-Schisandrin) is a dibenzocyclooctadiene derivative isolated from Fructus Schisandrae, has been shown to produce antioxidant effect on rodent liver and heart. IC50 value: Target: in vitro: Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. SB inhibited mitogen-induced proliferation and cytokine secretion by lymphocytes [1]. Sch B can protect neuronal cells against oxidative challenge, presumably by functioning as a hormetic agent to sustain cellular redox homeostasis and mitoenergetic capacity in neuronal cells [2]. Sch B exerted significant neuroprotective effects against microglial-mediated inflammatory injury in microglia-neuron co-cultures. Sch B significantly downregulated pro-inflammatory cytokines, including nitrite oxide (NO), tumor necrosis factor (TNF)-α, prostaglandin E(2) (PGE(2)), interleukin (IL)-1β and IL-6 [3]. Sch B could inhibit TGF-β induced EMT of 4T1 cells and of primary human breast cancer cells [4]. in vivo: Similar anti-inflammatory effects of SB on lymphocyte proliferation and cytokine secretion were also observed in vivo [1]. Treatment with Sch B in CsA-treated mice significantly suppressed the elevation of blood urea nitrogen (BUN) and serum creatinine levels and attenuated the histopathological changes. Additionally, Sch B also decreased renal MDA levels and increased GSH levels in CsA-treated mice [5].

    Molecular Weight

    400.46

    Formula

    C₂₃H₂₈O₆

    CAS No.

    61281-37-6

    SMILES

    CC(C1)C(C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 14.29 mg/mL (35.68 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4971 mL 12.4856 mL 24.9713 mL
    5 mM 0.4994 mL 2.4971 mL 4.9943 mL
    10 mM 0.2497 mL 1.2486 mL 2.4971 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 1.43 mg/mL (3.57 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 1.43 mg/mL (3.57 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    Schisandrin Bγ-SchisandrinWuweizisu BAutophagyReactive Oxygen SpeciesInhibitorinhibitorinhibit

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    Product Name:
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    Cat. No.:
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