82425-45-4
Chemical Structure
Gomisin M2
Synonym(s): (+)-Gomisin M2
- CAS No.: 82425-45-4
- Formula:C22H26O6
- Molecular Weight:386.44
IUPAC Name: (6S,7R)-1,2,3-trimethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3',4']cycloocta[1',2':4,5]benzo[1,2-d][1,3]dioxol-13-ol
InChIKey: PDDXWOMYBJCSQB-NEPJUHHUSA-N
SMILES: OC1=C(OCO2)C2=CC3=C1C4=C(OC)C(OC)=C(OC)C=C4C[C@H](C)[C@H](C)C3
Biological Activity: Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra chinensis with oral availability. Gomisin M2 inhibits STAT1 phosphorylation as well as NF-κB p65 phosphorylation and nuclear translocation. Gomisin M2 reduces inflammatory cell infiltration, cytokine and chemokine expression, and serum IgE and IgG2a levels. Gomisin M2 inhibits MAPK phosphorylation, IκBα degradation, and NF-κB nuclear translocation in keratinocytes. Gomisin M2 induces apoptosis, mitochondrial membrane potential disruption, and cytochrome c release, and inhibits DNA synthesis and mammosphere formation through downregulation of Wnt/β-catenin. Gomisin M2 can be used for research on atopic dermatitis, psoriasis, breast cancer, liver injury, and multidrug-resistant mammary adenocarcinoma[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Gomisin M2 | 99.75% | Gomisin M2 ((+)-Gomisin M2) is a lignan isolated from the fruits of Schisandra chinensis with oral availability. Gomisin M2 inhibits STAT1 phosphorylation as well as NF-κB p65 phosphorylation and nuclear translocation. Gomisin M2 reduces inflammatory cell infiltration, cytokine and chemokine expression, and serum IgE and IgG2a levels. Gomisin M2 inhibits MAPK phosphorylation, IκBα degradation, and NF-κB nuclear translocation in keratinocytes. Gomisin M2 induces apoptosis, mitochondrial membrane potential disruption, and cytochrome c release, and inhibits DNA synthesis and mammosphere formation through downregulation of Wnt/β-catenin. Gomisin M2 can be used for research on atopic dermatitis, psoriasis, breast cancer, liver injury, and multidrug-resistant mammary adenocarcinoma. | ||||||||||||||||||||
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References
- [1]. Dhakal H. Gomisin M2 inhibits mast cell-mediated allergic inflammation via attenuation of FcεRI-mediated Lyn and Fyn activation and intracellular calcium levels. Frontiers in pharmacology. 2019 Aug 2;10:869.
- [2]. Kim N, et al. Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways. Molecular medicine reports. 2021 Dec;24(6):859.
- [3]. Kim N, et al. Gomisin M2 ameliorates imiquimod-induced psoriasis-like skin inflammation via the inhibition of mitogen-activated protein kinase. FASEB J. 2019 Apr 1;33(1 Suppl):lb47.
- [4]. Yang Y, et al. Gomisin M2 from Baizuan suppresses breast cancer stem cell proliferation in a zebrafish xenograft model. Aging. 2019 Oct 14;11(19):8347-8361.
- [5]. Li F, et al. A New Nortriterpenoid, a Sesquiterpene and Hepatoprotective Lignans Isolated from the Fruit of Schisandra chinensis. Molecules (Basel, Switzerland). 2017 Nov 10;22(11):1931.
- [6]. Wu CM. Lignans and sesquiterpenes from Schisandra tomentella AC Smith. Fitoterapia. 2022 Apr 1;158:105142.
