Schisanhenol B

Cat. No.: HY-N0859A: Data Sheet Handling Instructions
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Schisanhenol B is one of the active ingredients of schisandra chinensis. Schisanhenol B is a tyrosinase inhibitor. Schisanhenol B has good binding activity with PIK3CG and can be used in the study of heart failure.

For research use only. We do not sell to patients.

Schisanhenol B Chemical Structure

CAS No. : 102681-52-7

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This product is a controlled substance and not for sale in your territory.

Other Forms of Schisanhenol B:

Schisanhenol In-stock
Schisanchinin D Get quote

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•Related Small Molecules:

•Related Proteins:

View All PI3K Isoform Specific Products:

View All Isoforms

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human A549 cells after 3 days by MTT assay Cytotoxicity against human A549 cells after 3 days by MTT assay	[PMID: 23738539]
H9	EC₅₀	< 0.65 μM Compound: 4	Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA	[PMID: 17190445]
H9	IC₅₀	44.5 μM Compound: 4	Cytotoxicity against human H9 cells after 4 days Cytotoxicity against human H9 cells after 4 days	[PMID: 17190445]
HCT-116	IC₅₀	55.38 μM Compound: GM	Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
HeLa	IC₅₀	17.15 μM Compound: GM	Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay	[PMID: 34038111]
HeLa	IC₅₀	32.83 μM Compound: GM	Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
HepG2	IC₅₀	27.26 μM Compound: GM	Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
Huh-7	IC₅₀	32.23 μM Compound: GM	Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
MCF7	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 23738539]
MDA-MB-231	IC₅₀	56.61 μM Compound: GM	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
MHCC97	IC₅₀	24.75 μM Compound: GM	Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
NB-4	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human NB4 cells after 3 days by MTT assay Cytotoxicity against human NB4 cells after 3 days by MTT assay	[PMID: 23738539]
PC-3	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human PC3 cells after 3 days by MTT assay Cytotoxicity against human PC3 cells after 3 days by MTT assay	[PMID: 23738539]
SH-SY5Y	IC₅₀	> 10 μM Compound: 11	Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay	[PMID: 23738539]
SK-HEP1	IC₅₀	20.56 μM Compound: GM	Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]

Molecular Weight

386.44

Formula

C₂₂H₂₆O₆

CAS No.

102681-52-7

SMILES

OC1=C(C(OC)=CC2=C1C3=C(C4=C(C=C3C[C@@H]([C@@H](C2)C)C)OCO4)OC)OC

Structure Classification

Phenols

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wen S, et al. Investigating the Mechanism of Action of Schisandra chinensis Combined with Coenzyme Q10 in the Treatment of Heart Failure Based on PI3K-AKT Pathway. Drug Des Devel Ther. 2023 Mar 27;17:939-957. [Content Brief]

[2]. Sobstyl E, et al. Chromatographic and Biological Screening of Chosen Species of Schisandraceae Family: Schisandra chinensis, S. rubriflora, S. sphenanthera, S. henryi and Kadsura japonica. Chem Biodivers. 2023 Oct;20(10):e202300741. [Content Brief]

Schisanhenol B Related Classifications

Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Schisanhenol B102681-52-7PI3KTyrosinasePhosphoinositide 3-kinaseschisandra chinensisInhibitorinhibitorinhibit

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