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Cat. No.: HY-N0859A

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Schisanhenol B

Schisanhenol B is one of the active ingredients of schisandra chinensis. Schisanhenol B is a tyrosinase inhibitor. Schisanhenol B has good binding activity with PIK3CG and can be used in the study of heart failure.

For research use only. We do not sell to patients.

CAS No.: 102681-52-7
Formula: C₂₂H₂₆O₆
Molecular Weight:386.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Schisanhenol B Chemical Structure

CAS No.: 102681-52-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

All PI3K Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human A549 cells after 3 days by MTT assay Cytotoxicity against human A549 cells after 3 days by MTT assay	[PMID: 23738539]
HCT-116	IC₅₀	55.38 μM Compound: GM	Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
HeLa	IC₅₀	17.15 μM Compound: GM	Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay	[PMID: 34038111]
HeLa	IC₅₀	32.83 μM Compound: GM	Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
HepG2	IC₅₀	27.26 μM Compound: GM	Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
Huh-7	IC₅₀	32.23 μM Compound: GM	Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
MCF7	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 23738539]
MDA-MB-231	IC₅₀	56.61 μM Compound: GM	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
MHCC97	IC₅₀	24.75 μM Compound: GM	Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
NB-4	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human NB4 cells after 3 days by MTT assay Cytotoxicity against human NB4 cells after 3 days by MTT assay	[PMID: 23738539]
PC-3	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human PC3 cells after 3 days by MTT assay Cytotoxicity against human PC3 cells after 3 days by MTT assay	[PMID: 23738539]
SH-SY5Y	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay	[PMID: 23738539]
SK-HEP1	IC₅₀	20.56 μM Compound: GM	Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]

Chemical Information

CAS No. 102681-52-7
Molecular Weight 386.44
Formula C₂₂H₂₆O₆
SMILES

OC1=C(C(OC)=CC2=C1C3=C(C4=C(C=C3C[C@@H]([C@@H](C2)C)C)OCO4)OC)OC
Structure Classification
- Phenylpropanoids
- Lignans
- Phenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Signal Pathway Related

Research Protocol for Cardiovascular Diseases
Cardiovascular disease can be modeled as maladaptive cardiac remodeling, where ischemic injury or pressure overload activates inflammatory signaling, fibroblast activation, extracellular-matrix deposition, cardiomyocyte hypertrophy, vascular remodeling, and progressive ventricular dysfunction. The TGF-β/SMAD axis is a central profibrotic pathway after myocardial injury and pressure overload, while innate immune and cytokine pathways regulate leukocyte recruitment, scar formation, and adverse remodeling. Key unresolved questions include which inflammatory signals are reparative versus harmful, when fibrosis is protective versus maladaptive, and whether pathway inhibition improves function without weakening necessary infarct healing or compensatory remodeling.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Wen S, et al. Investigating the Mechanism of Action of Schisandra chinensis Combined with Coenzyme Q10 in the Treatment of Heart Failure Based on PI3K-AKT Pathway. Drug Des Devel Ther. 2023 Mar 27;17:939-957. [Content Brief]

[2]. Sobstyl E, et al. Chromatographic and Biological Screening of Chosen Species of Schisandraceae Family: Schisandra chinensis, S. rubriflora, S. sphenanthera, S. henryi and Kadsura japonica. Chem Biodivers. 2023 Oct;20(10):e202300741. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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