Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta

  • J Nat Prod. 2013 Jun 28;76(6):1052-7. doi: 10.1021/np400070x.
Xue-Mei Gao  1 ,  Rui-Rui Wang ,  De-Yun Niu ,  Chun-Yang Meng ,  Liu-Meng Yang ,  Yong-Tang Zheng ,  Guang-Yu Yang ,  Qiu-Fen Hu ,  Han-Dong Sun ,  Wei-Lie Xiao
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
PMID: 23738539 DOI: 10.1021/np400070x
Abstract

Seven new unusual dibenzocyclooctadiene Lignans, neglignans A-G (1-7), together with 16 known dibenzocyclooctadiene Lignans, were isolated from the stems of Schisandra neglecta. Compounds 1 and 2 are the first dibenzocyclooctadiene Lignans bearing a carboxyl group at C-4, and compounds 3 and 4 are the first 7,8-seco-dibenzocyclooctadiene Lignans found from Nature. The new compounds (1-7) and several of the known compounds were evaluated for their anti-HIV activity and cytotoxicity. Compounds 2 and 6 showed anti-HIV-1 activities with therapeutic index values greater than 50, and compound 4 showed cytotoxicity against the NB4 and SHSY5Y Cancer cell lines with IC50 values of 2.9 and 3.3 μM, respectively.