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Art. -Nr.: HY-N1529

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Gomisin M1

(Synonyms: (±)-Gomisin M1)

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Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC₅₀ of <0.65 μM.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 99.75%
CAS. Nr.: 82467-50-3
Formel: C₂₂H₂₆O₆
Molecular Weight:386.44

Speicherung:

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Gomisin M1 Chemical Structure

CAS. Nr.: 82467-50-3

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Gomisin M1 ((±)-Gomisin M1) is a potent anti-HIV agent with an EC₅₀ of <0.65 μM^[1].

IC₅₀ & Target^[1]

HIV-1

Alle HIV Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human A549 cells after 3 days by MTT assay Cytotoxicity against human A549 cells after 3 days by MTT assay	[PMID: 23738539]
H9	EC₅₀	<0.65 μM Compound: 4	Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA Antiviral activity against HIV1 3B in H9 cells after 4 days by p24-antigen ELISA	[PMID: 17190445]
H9	IC₅₀	44.5 μM Compound: 4	Cytotoxicity against human H9 cells after 4 days Cytotoxicity against human H9 cells after 4 days	[PMID: 17190445]
HCT-116	IC₅₀	55.38 μM Compound: GM	Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HCT-116 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
HeLa	IC₅₀	17.15 μM Compound: GM	Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay Antiproliferative activity against human HeLa cells assessed as increase in miR-21 biogenesis level measured after 24 hrs by luciferase assay	[PMID: 34038111]
HeLa	IC₅₀	32.83 μM Compound: GM	Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HeLa cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
HepG2	IC₅₀	27.26 μM Compound: GM	Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human HepG2 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
Huh-7	IC₅₀	32.23 μM Compound: GM	Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human Huh-7 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
MCF7	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human MCF7 cells after 3 days by MTT assay Cytotoxicity against human MCF7 cells after 3 days by MTT assay	[PMID: 23738539]
MDA-MB-231	IC₅₀	56.61 μM Compound: GM	Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human MDA-MB-231 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
MHCC97	IC₅₀	24.75 μM Compound: GM	Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human MHCC97 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]
NB-4	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human NB4 cells after 3 days by MTT assay Cytotoxicity against human NB4 cells after 3 days by MTT assay	[PMID: 23738539]
PC-3	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human PC3 cells after 3 days by MTT assay Cytotoxicity against human PC3 cells after 3 days by MTT assay	[PMID: 23738539]
SH-SY5Y	IC₅₀	>10 μM Compound: 11	Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay Cytotoxicity against human SH-SY5Y cells after 3 days by MTT assay	[PMID: 23738539]
SK-HEP1	IC₅₀	20.56 μM Compound: GM	Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay Antiproliferative activity against human SK-HEP1 cells incubated for 24 hrs by alamar blue assay	[PMID: 34038111]

In Vitro

Gomisin M1 ((±)-Gomisin M1) (4 days) shows anti-HIV-1 activity with an EC₅₀ of <0.65 μM in H9 T cell lines and therapeutic index (TI) is >68^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 82467-50-3
Appearance Solid
Molecular Weight 386.44
Formel C₂₂H₂₆O₆
Color White to off-white
SMILES

OC1=C(C2=C3C=C4OCOC4=C2OC)C(CC(C)C(C)C3)=CC(OC)=C1OC
Synonyms

(±)-Gomisin M1
Structure Classification
- Phenylpropanoids
- Lignans
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 17.2 mg/mL (44.51 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.5877 mL

12.9386 mL

25.8772 mL

5 mM

0.5175 mL

2.5877 mL

5.1754 mL

10 mM

0.2588 mL

1.2939 mL

2.5877 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen M, et al. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. J Nat Prod. 2006 Dec;69(12):1697-701. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.5877 mL	12.9386 mL	25.8772 mL	64.6931 mL
	5 mM	0.5175 mL	2.5877 mL	5.1754 mL	12.9386 mL
	10 mM	0.2588 mL	1.2939 mL	2.5877 mL	6.4693 mL
	15 mM	0.1725 mL	0.8626 mL	1.7251 mL	4.3129 mL
	20 mM	0.1294 mL	0.6469 mL	1.2939 mL	3.2347 mL
	25 mM	0.1035 mL	0.5175 mL	1.0351 mL	2.5877 mL
	30 mM	0.0863 mL	0.4313 mL	0.8626 mL	2.1564 mL
	40 mM	0.0647 mL	0.3235 mL	0.6469 mL	1.6173 mL

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise

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Gomisin M1

MCE Bioactive Compound Library

Natural Product Library Plus

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Gomisin M1

MCE Bioactive Compound Library

Natural Product Library Plus

Alle HIV Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Gomisin M1 Related Classifications

HY-N1529 Related Classifications