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Results for "

Sec61

" in MedChemExpress (MCE) Product Catalog:

17

Inhibitors & Agonists

4

Peptides

1

Natural
Products

2

Antibodies

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-110078
    Eeyarestatin I
    10+ Cited Publications

    		 p97 Apoptosis Cancer
    Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .
    Eeyarestatin I
  • HY-176763
    KZR-261

    		Sec61 Cancer
    KZR-261 is a Sec61 translocase inhibitor. KZR-261 binds directly to the Sec61 channel, thereby inhibiting the biosynthesis of certain Sec61 substrate proteins, including oncogenic factors. KZR-261 activates the endoplasmic reticulum stress response. KZR-261 exhibits broad in vitro anticancer activity. KZR-261 shows antitumor efficacy in mouse models of cancer. KZR-261 can be used for the research of multiple myeloma, colorectal cancer, small cell lung cancer, pancreatic cancer, prostate cancer, non-Hodgkin's lymphoma, and mantle cell lymphoma .
    KZR-261
  • HY-134809
    Cyclotriazadisulfonamide

    CADA

    		 HIV Infection Inflammation/Immunology
    Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor .
    Cyclotriazadisulfonamide
  • HY-139615
    Sec61-IN-1

    		Sec61 Cancer
    Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].
    Sec61-IN-1
  • HY-N10661
    Ipomoeassin F

    Ipom-F

    		 SARS-CoV Infection Cancer
    Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .
    Ipomoeassin F
  • HY-139616
    Sec61-IN-2

    		Sec61 Others
    Sec61-IN-2 (A347) is a protein secretion inhibitor (extracted from patent WO2020176863) .
    Sec61-IN-2
  • HY-139617
    Sec61-IN-3

    		Sec61 Others
    Sec61-IN-2 (A3) is a protein secretion inhibitor (extracted from patent WO2020176863) .
    Sec61-IN-3
  • HY-156349
    Sec61-IN-4

    		Apoptosis Others
    Sec61-IN-4 (Compound 16b) is a Sec61 inhibitor (IC50: 0.04 nM in U87-MG cells) .
    Sec61-IN-4
  • HY-156355
    Sec61-IN-5

    		Others Cancer
    Sec61-IN-5 (Compound 16c) is a Sec61 inhibitor. Sec61 shows cytotoxicity in A549 cells (IC50: 0.27 nM). Sec61-IN-5 inhibits Sec61-dependent secretory function (IC50: 0.08 nM) .
    Sec61-IN-5
  • HY-RS12623
    SEC61G Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SEC61G Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SEC61G Human Pre-designed siRNA Set A
    SEC61G Human Pre-designed siRNA Set A
  • HY-RS12621
    SEC61A1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SEC61A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SEC61A1 Human Pre-designed siRNA Set A
    SEC61A1 Human Pre-designed siRNA Set A
  • HY-RS12622
    SEC61B Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SEC61B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SEC61B Human Pre-designed siRNA Set A
    SEC61B Human Pre-designed siRNA Set A
  • HY-P3987A
    Cotransin TFA

    		Sec61 Cancer
    Cotransin TFA is a cyclic ester peptide and a Sec61 translocator binder with signal sequence-selective activity to inhibit co-translational protein translocation. Cotransin TFA inhibits the biogenesis of a subset of secretory and membrane proteins in a signal peptide-dependent manner. Cotransin TFA is applicable for cancer-related research .
    Cotransin TFA
  • HY-182690
    CK147

    		HIV Infection
    CK147 is a Sec61α translocase inhibitor that blocks the co-translational translocation of proteins by binding to and inhibiting the Sec61 protein translocation channel on the endoplasmic reticulum membrane. CK147 exhibits potent CD4 downregulation activity with an IC50 of 0.04 µM. CK147 prevents HIV entry into host cells and shows significant cytotoxicity. CK147 can be used in studies related to HIV infection .
    CK147
  • HY-P10466A
    KZR-8445 TFA

    		Sec61 SARS-CoV Interleukin Related TNF Receptor IFNAR Infection Inflammation/Immunology
    KZR-8445 TFA, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 TFA binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 TFA inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 TFA inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 TFA blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 TFA can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection .
    KZR-8445 TFA
  • HY-P10466
    KZR-8445

    		Sec61 SARS-CoV Interleukin Related TNF Receptor IFNAR Infection Inflammation/Immunology
    KZR-8445, a cyclic depsipeptide, is a client-selective Sec61 inhibitor. KZR-8445 binds to the fully opened Sec61 lateral gate, blocks lumenal plug domain access, stabilizes lateral gate helices, traps select signal peptides, and disrupts secretory and membrane protein biogenesis. KZR-8445 inhibits pro-inflammatory cytokine secretion in primary immune cells. KZR-8445 inhibits SARS-CoV-2 replication, virus-induced cytotoxicity, and spike protein biogenesis. KZR-8445 blocks disease progression in a mouse model of rheumatoid arthritis. KZR-8445 can be used for the researches of rheumatoid arthritis and SARS-CoV-2 infection .
    KZR-8445
  • HY-182674
    VGD020

    		Sec61 HIV Flavivirus Neurotensin Receptor Infection Cancer
    VGD020 is a highly potent and selective Sec61 translocon inhibitor . VGD020 suppresses the expression of cell surface CD4 by inhibiting signal peptide-dependent co-translational ER translocation, interferes with the initiation of ER translocation of dengue virus polyprotein, and reduces the expression of Sortilin in breast cancer cells. VGD020 exhibits broad anti-flavivirus and anti-HIV activities. VGD020 can be used in research related to dengue virus infection, Zika virus infection, yellow fever virus infection, human immunodeficiency virus infection, and breast cancer .
    VGD020

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