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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Sec61
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Sec61" in MCE Product Catalog:
15
15 Cited Publications
Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. Eeyarestatin I inhibits Sec61 translocon. Eeyarestatin I targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination. Eeyarestatin I interferes at a step prior to proteasomal degradation. Eeyarestatin I induces cell death via the proapoptotic protein NOXA and has anticancer effects .
Cat. No.: HY-176763
CAS No.: 2376747-46-3
KZR-261 is a Sec61 translocase inhibitor. KZR-261 binds directly to the Sec61 channel, thereby inhibiting the biosynthesis of certain Sec61 substrate proteins, including oncogenic factors. KZR-261 activates the endoplasmic reticulum stress response. KZR-261 exhibits broad in vitro anticancer activity. KZR-261 shows antitumor efficacy in mouse models of cancer. KZR-261 can be used for the research of multiple myeloma, colorectal cancer, small cell lung cancer, pancreatic cancer, prostate cancer, non-Hodgkin's lymphoma, and mantle cell lymphoma .
Synonyms: CADA
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Cyclotriazadisulfonamide (CADA) is a specific CD4-targeted HIV entry inhibitors. Cyclotriazadisulfonamide (CADA) inhibits the co-translational translocation of human CD4 (huCD4) into the ER lumen in a signal peptide (SP)-dependent way. Cyclotriazadisulfonamide is also a Sec61 translocon inhibitor .
Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].
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Sec61-IN-2 is a Sec61 inhibitor. Sec61-IN-2 shows a significant inhibitory effect on PD-1 related reporter gene cell models (PD1tsGluc) (IC50 = 42 nM), while it has almost no inhibitory activity in TNFα, Her3, and IL-2 pathway models. Sec61-IN-2 can be used for cancer research .
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Sec61-IN-3 is a Sec61 inhibitor. Sec61-IN-3 shows a significant inhibitory effect on PD-1 related reporter gene cell models (PD1tsGluc) (IC50 = 42 nM), and also has certain inhibitory activity on Her3 (IC50 = 99 nM), IL2 (IC50 = 144 nM) related reporter pathways, but has a relatively weak inhibitory effect on the TNFα (IC50 = 580 nM) pathway. Sec61-IN-3 can be used for cancer research .
Cat. No.: HY-RS12623
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SEC61G Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61G gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P10477
CAS No.: 1000770-96-6
Cat. No.: HY-RS12621
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SEC61A1 Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS12622
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SEC61B Human Pre-designed siRNA Set A contains three designed siRNAs for SEC61B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P87069
Synonyms: chunp6898 antibody; fb62c11 antibody; HSec61 antibody; protein transport protein Sec61 alpha subunit antibody; protein transport protein Sec61 subunit alpha antibody; Protein transport protein Sec61 subunit alpha isoform 1 antibody; S61A1_HUMAN antibody; Sec 61 antibody; Sec 61A antibody; Sec61 alpha 1 antibody; chunp6898 antibody; fb62c11 antibody; HSec61 antibody; protein transport protein Sec61 alpha subunit antibody; protein transport protein Sec61 subunit alpha antibody; Protein transport protein Sec61 subunit alpha isoform 1 antibody; S61A1_HUMAN antibody; Sec 61 antibody; Sec 61A antibody; Sec61 alpha 1 antibody; Sec61 alpha 1 subunit antibody; Sec61 alpha 1 subunit (S. cerevisiae) antibody; Sec61 alpha-1 antibody; Sec61 antibody; Sec61 homolog antibody; Sec61A1 antibody; Sec61aa antibody;
Cat. No.: HY-P3987A
Cat. No.: HY-182690
CAS No.: 1883356-12-4
CK147 is a Sec61α translocase inhibitor that blocks the co-translational translocation of proteins by binding to and inhibiting the Sec61 protein translocation channel on the endoplasmic reticulum membrane. CK147 exhibits potent CD4 downregulation activity with an IC50 of 0.04 µM. CK147 prevents HIV entry into host cells and shows significant cytotoxicity. CK147 can be used in studies related to HIV infection .
Cat. No.: HY-P10466
CAS No.: 2377734-91-1
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Cat. No.: HY-P10466A
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Cat. No.: HY-182674
CAS No.: 1322645-32-8
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VGD020 is a highly potent and selective Sec61 translocon inhibitor . VGD020 suppresses the expression of cell surface CD4 by inhibiting signal peptide-dependent co-translational ER translocation, interferes with the initiation of ER translocation of dengue virus polyprotein, and reduces the expression of Sortilin in breast cancer cells. VGD020 exhibits broad anti-flavivirus and anti-HIV activities. VGD020 can be used in research related to dengue virus infection, Zika virus infection, yellow fever virus infection, human immunodeficiency virus infection, and breast cancer .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
