1000770-96-6
1000770-96-6
Chemical Structure
CT-08
- CAS No.: 1000770-96-6
- Formula:C50H80N6O8
- Molecular Weight:893.21
InChIKey: FKOWLFBDYYDNSC-ASFFCJJISA-N
SMILES: O=C(N[C@H](C(N([C@H](C(O[C@@H](C(N[C@H](C(N([C@H](C(N[C@H](C(N1C)=O)CC(C)C)=O)CC(C)C)C)=O)C[C@H](C)CCCC)=O)CC#C)=O)C)C)=O)C[C@H](C)CCCC)[C@@H]1CC2=CC=CC=C2
Biological Activity: CT-08 (CT8, Compound 3) is a macrocyclic Sec61 modulator, blocks protein secretion in a signal sequence-dependent manner. CT-08 blocks Sec61-mediated translocation of VCAMss-GLuc into the ER, resulting in a loss of luciferase activity. CT-08 inhibits VCAM expression in transfected cells[1][2].
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CT-08 | CT-08 (CT8, Compound 3) is a macrocyclic Sec61 modulator, blocks protein secretion in a signal sequence-dependent manner. CT-08 blocks Sec61-mediated translocation of VCAMss-GLuc into the ER, resulting in a loss of luciferase activity. CT-08 inhibits VCAM expression in transfected cells. | |||||||||||||||||||||
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References
- [1]. Dustin Mcminn, et al. Preparation of thiazole carboxamides as protein secretion inhibitors for treatment of cancer and inflammation. WO2019046668A1. 2019-03-07.
- [2]. MacKinnon AL, et al. Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation. J Am Chem Soc. 2007 Nov 28;129(47):14560-1. [Content Brief]
