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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
21 Results for "
Spironolactone
" in MedChemExpress (MCE) Product Catalog:
Products (21)
21 Results for "Spironolactone" in MCE Product Catalog:
7
Research Areas:
Cardiovascular Disease Metabolic Disease Endocrinology Cancer
Spironolactone is an aldosterone antagonist that acts on the aldosterone mineralocorticoid receptor (IC50=24 nM) and androgen receptor (IC50=77 nM), promotes podocyte autophagy and regulates pain. Spironolactone improves hypertension-related vascular hypertrophy and remodeling by reducing angiotensin II (Ang II)-induced inflammation, reduces aldosterone-induced vascular and soft tissue calcification through PIT1-dependent signaling, and alleviates vascular dysfunction in type II diabetic mice by reducing oxidative stress and restoring NO/GC signaling; at low concentrations, it and its metabolites can interfere with aldosterone biosynthesis in the adrenal cortex and inhibit voltage-dependent Ca 2+ channels to exert antihypertensive effects .
Research Areas:
Spironolactone (Standard) is the analytical standard of Spironolactone. This product is intended for research and analytical applications. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes .
Cat. No.: HY-W739985
CAS No.: 38753-77-4
Synonyms: 7α-ThiomethylSpironolactone
Target:
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7α-(Thiomethyl)spironolactone is a nuclear steroid receptor antagonist that can be used for the research of coronaviruses .
Cat. No.: HY-P3990
CAS No.: 1029227-48-2
Cat. No.: HY-B0561S1
Synonyms: SC9420-d3
Cat. No.: HY-B0111S
CAS No.: 2376035-94-6
Synonyms: Dihydrospirorenone-d4
Cat. No.: HY-142515S
Synonyms: DeacetylSpironolactone; MercaptoSpironolactone
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7α-Thiospironolactone is the transformation product of spironolactone (HY-B0561), which can be obtained by the metabolism of Thermomyces lanuginosus .
Cat. No.: HY-B0561S
Synonyms: SC9420-d7
Cat. No.: HY-B0561S4
Cat. No.: HY-P1193
CAS No.: 129623-01-4
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Cat. No.: HY-156250S
Cat. No.: HY-B0561S2
Synonyms: SC9420-d3-1
Cat. No.: HY-P1720
CAS No.: 19246-24-3
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Cat. No.: HY-B0111RS
Synonyms: Dihydrospirorenone-13C3
Cat. No.: HY-P1709
CAS No.: 141912-59-6
Category:
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Cat. No.: HY-185277
CAS No.: 42219-60-3
Target:
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6β-Hydroxy-7α-thiomethylspirolactone is a metabolite of Spironolactone (HY-B0561). 6β-Hydroxy-7α-thiomethylspirolactone can be used in studies of cirrhotic ascites .
Cat. No.: HY-106593
CAS No.: 40574-52-5
Synonyms: SC 23133
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Prorenone (SC 23133) is a spironolactone-type steroidal mineralocorticoid receptor (MR) antagonist that can cross the blood-brain barrier, with low affinity for glucocorticoid receptors and rat prostate androgen receptors. Prorenone inhibits the binding and action of Aldosterone (HY-113313), blocks its induced nuclear receptor activity and stimulated sodium transport, antagonizes aldosterone-induced urinary potassium excretion, and prevents aldosterone-induced elevation of blood pressure. Prorenone can be used in research related to hypertension .
Cat. No.: HY-P11022
CAS No.: 55599-68-3
Synonyms: A-3302-B
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
