7α-(Thiomethyl)spironolactone
Based on 1 Customer Validation
7α-(Thiomethyl)spironolactone is a nuclear steroid receptor antagonist that can be used for the research of coronaviruses.
For research use only. We do not sell to patients.
- Purity: 99.80%
- CAS No.: 38753-77-4
- Formula: C23H32O3S
- Molecular Weight:388.56
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-130465
7α-Thiospironolactone
-
HY-W012264
3-O-Methyldopa monohydrate
-
HY-126857
5-Hydroxyomeprazole
-
HY-W016033
Pantoprazole sulfide
-
HY-W008614
Lansoprazole sulfone
-
HY-141554
Dihydrotetrabenazine
-
HY-W008614R
Lansoprazole sulfone (Standard)
-
HY-126857R
5-Hydroxyomeprazole (Standard)
-
HY-117225
Pantoprazole sulfone
Biological Activity
Nuclear Steroid Receptor[1]
Chemical Information
-
CAS No. 38753-77-4
-
Appearance Solid
-
Molecular Weight 388.56
-
Formula C23H32O3S
-
Color White to off-white
-
SMILES
C[C@@]12[C@@]3(OC(CC3)=O)CC[C@@]1([H])[C@@]4([H])[C@]([C@@]5(C(C[C@H]4SC)=CC(CC5)=O)C)([H])CC2
-
Synonyms
7α-Thiomethylspironolactone
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (257.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (277 KB)
-
SDS (558 KB)
- English - EN (558 KB)
- Français - FR (558 KB)
- Deutsch - DE (558 KB)
- Norwegian - NO (558 KB)
- Español - ES (558 KB)
- Swedish - SV (558 KB)
- Italian - IT (558 KB)
- Korean - KR (558 KB)
- Portuguese - PT (558 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5736 mL | 12.8680 mL | 25.7361 mL | 64.3401 mL |
| 5 mM | 0.5147 mL | 2.5736 mL | 5.1472 mL | 12.8680 mL | |
| 10 mM | 0.2574 mL | 1.2868 mL | 2.5736 mL | 6.4340 mL | |
| 15 mM | 0.1716 mL | 0.8579 mL | 1.7157 mL | 4.2893 mL | |
| 20 mM | 0.1287 mL | 0.6434 mL | 1.2868 mL | 3.2170 mL | |
| 25 mM | 0.1029 mL | 0.5147 mL | 1.0294 mL | 2.5736 mL | |
| 30 mM | 0.0858 mL | 0.4289 mL | 0.8579 mL | 2.1447 mL | |
| 40 mM | 0.0643 mL | 0.3217 mL | 0.6434 mL | 1.6085 mL | |
| 50 mM | 0.0515 mL | 0.2574 mL | 0.5147 mL | 1.2868 mL | |
| 60 mM | 0.0429 mL | 0.2145 mL | 0.4289 mL | 1.0723 mL | |
| 80 mM | 0.0322 mL | 0.1609 mL | 0.3217 mL | 0.8043 mL | |
| 100 mM | 0.0257 mL | 0.1287 mL | 0.2574 mL | 0.6434 mL |
7α-(Thiomethyl)spironolactone Related Classifications
HY-W739985 Related Classifications
Powered by Bioz