40574-52-5
Chemical Structure
Prorenone
Synonym(s): SC 23133
- CAS No.: 40574-52-5
- Formula:C23H30O3
- Molecular Weight:354.49
IUPAC Name: (4aR,4bS,6aS,7R,9aS,9bR,9cR,10aR)-4a,6a-dimethyl-3,3',4,4a,4b,4',5,6,6a,8,9,9a,9b,9c,10,10a-hexadecahydro-2H,5'H-spiro[cyclopenta[a]cyclopropa[l]phenanthrene-7,2'-furan]-2,5'-dione
InChIKey: RRHHMFQGHCFGMH-VAFIVCJBSA-N
SMILES: C[C@@]12[C@]3(CC[C@]1([C@]4([C@](CC2)([C@]5(C)C([C@]6([C@@]4(C6)[H])[H])=CC(=O)CC5)[H])[H])[H])OC(=O)CC3
Biological Activity: Prorenone (SC 23133) is a spironolactone-type steroidal mineralocorticoid receptor (MR) antagonist that can cross the blood-brain barrier, with low affinity for glucocorticoid receptors and rat prostate androgen receptors. Prorenone inhibits the binding and action of Aldosterone (HY-113313), blocks its induced nuclear receptor activity and stimulated sodium transport, antagonizes aldosterone-induced urinary potassium excretion, and prevents aldosterone-induced elevation of blood pressure. Prorenone can be used in research related to hypertension[1][2].
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Prorenone | Prorenone (SC 23133) is a spironolactone-type steroidal mineralocorticoid receptor (MR) antagonist that can cross the blood-brain barrier, with low affinity for glucocorticoid receptors and rat prostate androgen receptors. Prorenone inhibits the binding and action of Aldosterone (HY-113313), blocks its induced nuclear receptor activity and stimulated sodium transport, antagonizes aldosterone-induced urinary potassium excretion, and prevents aldosterone-induced elevation of blood pressure. Prorenone can be used in research related to hypertension. | |||||||||||||||||||||
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- [1]. Gomez-Sanchez EP, et al. Intracerebroventricular infusion of aldosterone induces hypertension in rats. Endocrinology. 1986 Feb;118(2):819-23. [Content Brief]
- [2]. Claire M, et al. Mechanism of action of a new antialdosterone compound, prorenone. Endocrinology. 1979 Apr;104(4):1194-200. [Content Brief]
Keywords
