9 Results for "

Subchronic toxicity

" in MedChemExpress (MCE) Product Catalog:
Products (9)

9 Results for "Subchronic toxicity" in MCE Product Catalog:

11
11 Publications Verification
Cat. No.: HY-N0124
CAS No.: 19057-60-4
Synonyms: Collettiside III; CCRIS 4123
Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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3
3 Cited Publications
Cat. No.: HY-113236
CAS No.: 614-35-7
Purity:  98.04%
p-Synephrine is an orally active alkaloid dietary supplement without indirect sympathomimetic activity or cardiovascular stimulatory activity. p-Synephrine stimulates AMPK phosphorylation and mediates Glut4 translocation to increase glucose consumption and lactate production in skeletal muscle cells. p-Synephrine also downregulates the p38 MAPK and NF-κB signaling pathways to inhibit pro-inflammatory cytokine production and alter oxidative metabolism. p-Synephrine exhibits low subchronic toxicity in mice. p-Synephrine can be applied to research related to systemic inflammatory response syndrome, obesity, and type 2 diabetes .
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1
1 Cited Publications
Cat. No.: HY-W040269
CAS No.: 92-36-4
Synonyms: DHPT
Research Areas:  

Others

Dehydrothio-p-toluidine (DHPT) is a chemical intermediate used in dyestuff production. Dehydrothio-p-toluidine shows inhalation toxicity in acute and subchronic conditions .
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Cat. No.: HY-D1005A22
CAS No.: 9003-11-6
Synonyms: PEG-PPG-PEG, 14600 (Average)
Poloxamer 338 F108 is block polymer of polyoxyethylene and polyoxypropylene with average molecular mass of 14600. Poloxamer 338 F108 reduces the aggregation of red blood cells, inhibits proliferation of human lymphocyte cell IIBR1. Poloxamer 338 F108 exhibits short-term and subchronic toxicity in rats .
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Cat. No.: HY-152927
CAS No.: 71138-97-1
Purity:  ≥95.0%
Research Areas:  

Others

Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) is a cosolvent for preparing SDDs of low-solubility agents. Hydroxypropylmethyl cellulose acetate succinate (Mw: 20-100k Da) exhibits no acute/subchronic/chronic toxicity in rats, with oral activity and LD50 >2.5 g/kg .
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Cat. No.: HY-N0124R
CAS No.: 19057-60-4
Synonyms: Collettiside III (Standard); CCRIS 4123 (Standard)
Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity .
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Cat. No.: HY-P10759
CAS No.: 372491-73-1
Research Areas:  

Cancer

DTS-201 sodium (CPI-0004Na) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer .
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Cat. No.: HY-119034
CAS No.: 111542-07-5
Target:  

Drug Derivative

Research Areas:  

Cancer

AD-20 is an o-methoxyphenylacetyl dehydroalanine derivative. AD-20 can not only reduce the acute and subchronic toxicity of Doxorubicin (HY-15142A), but also enhance its anti-tumor effect .
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Cat. No.: HY-106154
CAS No.: 274912-87-7
Research Areas:  

Cancer

DTS-201 (CPI-0004) is a peptidic prodrug of Doxorubicin (HY-15142A). DTS-201, comprising the tetrapeptide portion, is cleaved by endopeptidases in the tumor environment to produce metabolites that subsequently enter the cell and are converted to active Doxorubicin. DTS-201 shows antitumoral efficacy in tumor xenograft models of prostate, breast, and lung cancer .
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