614-35-7
Chemical Structure
p-Synephrine
- CAS No.: 614-35-7
- Formula:C9H13NO2
- Molecular Weight:167.21
IUPAC Name: (R)-4-(1-hydroxy-2-(methylamino)ethyl)phenol
InChIKey: YRCWQPVGYLYSOX-VIFPVBQESA-N
SMILES: OC1=CC=C([C@@H](O)CNC)C=C1
Biological Activity: p-Synephrine is an orally active alkaloid dietary supplement without indirect sympathomimetic activity or cardiovascular stimulatory activity. p-Synephrine stimulates AMPK phosphorylation and mediates Glut4 translocation to increase glucose consumption and lactate production in skeletal muscle cells. p-Synephrine also downregulates the p38 MAPK and NF-κB signaling pathways to inhibit pro-inflammatory cytokine production and alter oxidative metabolism. p-Synephrine exhibits low subchronic toxicity in mice. p-Synephrine can be applied to research related to systemic inflammatory response syndrome, obesity, and type 2 diabetes[1][2][3][4].
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p-Synephrine | 99.90% | p-Synephrine is an orally active alkaloid dietary supplement without indirect sympathomimetic activity or cardiovascular stimulatory activity. p-Synephrine stimulates AMPK phosphorylation and mediates Glut4 translocation to increase glucose consumption and lactate production in skeletal muscle cells. p-Synephrine also downregulates the p38 MAPK and NF-κB signaling pathways to inhibit pro-inflammatory cytokine production and alter oxidative metabolism. p-Synephrine exhibits low subchronic toxicity in mice. p-Synephrine can be applied to research related to systemic inflammatory response syndrome, obesity, and type 2 diabetes. | ||||||||||||||||||||
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p-Synephrine (Standard) | ≥98% | p-Synephrine (Standard) is the analytical standard of p-Synephrine. This product is intended for research and analytical applications. p-Synephrine is an organic compound, found in multiple biofluids, such as urine and blood. | ||||||||||||||||||||
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References
- [1]. Stohs SJ, Shara M, Ray SD. p-Synephrine, ephedrine, p-octopamine and m-synephrine: Comparative mechanistic, physiological and pharmacological properties. Phytotherapy research : PTR. 2020 Aug;34(8):1838-1846. [Content Brief]
- [2]. Ishida M, Takekuni C, Nishi K, et al.. -Synephrine suppresses inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells and alleviates systemic inflammatory response syndrome in mice. Food & function. 2022 May 10;13(9):5229-5239. [Content Brief]
- [3]. Arbo MD, Schmitt GC, Limberger MF, et al.. Subchronic toxicity of Citrus aurantium L. (Rutaceae) extract and p-synephrine in mice. Regulatory toxicology and pharmacology : RTP. 2009 Jul;54(2):114-7. [Content Brief]
- [4]. Hong NY, Cui ZG, Kang HK, et al.. p-Synephrine stimulates glucose consumption via AMPK in L6 skeletal muscle cells. Biochemical and biophysical research communications. 2012 Feb 24;418(4):720-4. [Content Brief]
