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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
18 Results for "
TUB
" in MedChemExpress (MCE) Product Catalog:
Products (18)
18 Results for "TUB" in MCE Product Catalog:
Target:
Research Areas:
Silvestrol aglycone is a Silvestrol analogue, inhibits protein translation initiation in cancer cells, with EC50s of 10 and 200 nM for myc-LUC and tub-LUC luciferase reporter protein translation, respectively. Anti-cancer activity .
Research Areas:
eIF4A3-IN-9 is a Rocaglate analog. eIF4A3-IN-9 interferes with the assembly of the eIF4F translation complex, with EC50 values of 40 nM and > 2000 nM against myc-LUC and tub-LUC, respectively. eIF4A3-IN-9 can be used for the research of tumor pathogenesis .
Cat. No.: HY-148450
CAS No.: 1402931-74-1
Research Areas:
eIF4A3-IN-16 (compound 60) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-16 inhibits MBA-MB-231cell growth with an EC50 value of 1 nM. eIF4A3-IN-16 interferes the assembling of eIF4F translation complex with a myc-LUC EC50 value of 1 nM and a tub-LUC EC50 value of 30 nM. eIF4A3-IN-16 can be used for triple negative breast cancer (TNBC) research .
Cat. No.: HY-177413
CAS No.: 2361406-35-9
Research Areas:
Tub114 is a drug-linker conjugate for ADC. Tub114 is a Tubulysin B (HY-N1243) analog with a stable hydrophilic linker. Tub114 can be used for synthesis of ADCs .
Research Areas:
eIF4A3-IN-9 is a Rocaglate analog. eIF4A3-IN-9 interferes with the assembly of the eIF4F translation complex, with EC50 values of 29 and 450 nM against myc-LUC and tub-LUC, respectively. eIF4A3-IN-9 can be used for the research of tumor pathogenesis .
Cat. No.: HY-148446
CAS No.: 1402931-76-3
Research Areas:
eIF4A3-IN-12 (compound 62) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-12 interferes the assembling of eIF4F translation complex with EC50s of 4, 70 and 5 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-12 can be used for the research of human cancer pathogenesis .
Research Areas:
eIF4A3-IN-18 (compound 74) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis .
Cat. No.: HY-148451
CAS No.: 1402931-75-2
Research Areas:
eIF4A3-IN-17 (compound 61) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-17 interferes the assembling of eIF4F translation complex with EC50s of 0.9, 15 and 1.8 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-17 can be used for the research of human cancer pathogenesis .
Cat. No.: HY-RS17577
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Research Areas:
Tub Mouse Pre-designed siRNA Set A contains three designed siRNAs for Tub gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-175881
Target:
Research Areas:
3-Formyl-L-tyrosine-oxime-Val-Cit-PAPB is an ADC linker that can be used for the synthesis of the TUB-010 drug linker (HY-175884) .
Cat. No.: HY-175884
Target:
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TUB-010 drug-linker is a drug-linker conjugate for ADC, which comprises a mitotic inhibitor MMAE (HY-15162 )and a linker. TUB-010 drug-linker can be used for synthesis of ADC TUB-010 .
Cat. No.: HY-148445
CAS No.: 1402931-70-7
Research Areas:
eIF4A3-IN-11 (compound 56) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-11 interferes the assembling of eIF4F translation complex with EC50s of 0.2, 4 and 0.3 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-11 can be used for the research of human cancer pathogenesis .
Cat. No.: HY-RS15244
Target:
Research Areas:
TUB Human Pre-designed siRNA Set A contains three designed siRNAs for TUB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24037
Target:
Research Areas:
Tub Rat Pre-designed siRNA Set A contains three designed siRNAs for Tub gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-148449
CAS No.: 1402931-66-1
Research Areas:
eIF4A3-IN-15 (compound 52) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-15 interferes the assembling of eIF4F translation complex with EC50s of 11, 700 and 120 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-15 can be used for the research of human cancer pathogenesis .
Cat. No.: HY-168326
CAS No.: 1139263-21-0
Target:
Research Areas:
Antiproliferative agent-64 (Compound 76) is an inhibitor for eukaryotic translation initiation factor 4E (eIF4E), that block the secondary structure of mRNA, thereby inhibiting protein translation. Antiproliferative agent-64 inhibits the 5' untranslated region (5'UTR) of c-Myc (c-myc 5'UTR) with an EC50 of 1.2 nM, inhibits 5'UTR encoding tubulin (tub 5'UTR) with an EC50 of 40 nM. Antiproliferative agent-64 inhibits the proliferation of MDA-MB-231 with an EC50 of 7 nM .
Cat. No.: HY-P701073
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: TUBby protein homolog; TUB; RD5; RDOB
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
