1402931-84-3
Chemical Structure
eIF4A3-IN-18
- CAS. Nr.: 1402931-84-3
- Formula:C29H28N2O6
- Molecular Weight:500.54
IUPAC Name: (1R,2R,3S,3aR,8bS)-6-cyano-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-2,3,3a,8b-tetrahydro-1H-cyclopenta[b]benzofuran-2-carboxamide
InChIKey: PYRHQQZNFDRIGQ-IDAMAFBJSA-N
SMILES: COC1=CC=C([C@@]23OC4=CC(C#N)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(N(C)C)=O)O)C=C1
Biological Activity: eIF4A3-IN-18 (compound 74) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
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eIF4A3-IN-18 | 98.99% | eIF4A3-IN-18 (compound 74) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-18 interferes the assembling of eIF4F translation complex with EC50 values of 0.8, 35 and 2 nM for myc-LUC, tub-LUC and the growth inhibition for MBA-MB-231 cells. eIF4A3-IN-18 also has cytotoxicity to RMPI-8226 cells with an LC50 of 0.06 nM. eIF4A3-IN-18 can be used for the research of human cancer pathogenesis. | ||||||||||||||||||||
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Similarity Score 0.92
HY-168326Antiproliferative agent-64 -
Similarity Score 0.90
HY-148447eIF4A-IN-3 -
Similarity Score 0.89
HY-19356Rocaglamide -
Similarity Score 0.89
HY-19356B(+)-Rocaglamide -
Similarity Score 0.87
HY-148451eIF4A3-IN-17 -
Similarity Score 0.83
HY-148422Rohinitib -
Similarity Score 0.82
HY-N8939Desmethylrocaglamide -
Similarity Score 0.82
HY-19356ADidesmethylrocaglamide -
Similarity Score 0.81
HY-N1841Rocaglamide D -
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