1402931-74-1
Chemical Structure
eIF4A3-IN-16
- CAS No.: 1402931-74-1
- Formula:C29H28O8
- Molecular Weight:504.53
IUPAC Name: 6-chloro-3-iodopyrazolo[1,5-a]pyridine
InChIKey: JMTJQGAMQVTDMS-IDAMAFBJSA-N
SMILES: COC1=CC=C([C@@]23OC4=CC(C(C)=O)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(OC)=O)O)C=C1
Biological Activity: eIF4A3-IN-16 (compound 60) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-16 inhibits MBA-MB-231cell growth with an EC50 value of 1 nM. eIF4A3-IN-16 interferes the assembling of eIF4F translation complex with a myc-LUC EC50 value of 1 nM and a tub-LUC EC50 value of 30 nM. eIF4A3-IN-16 can be used for triple negative breast cancer (TNBC) research[1].
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eIF4A3-IN-16 | 99.96% | eIF4A3-IN-16 (compound 60) is a Silvestrol (HY-13251) analogue. eIF4A3-IN-16 inhibits MBA-MB-231cell growth with an EC50 value of 1 nM. eIF4A3-IN-16 interferes the assembling of eIF4F translation complex with a myc-LUC EC50 value of 1 nM and a tub-LUC EC50 value of 30 nM. eIF4A3-IN-16 can be used for triple negative breast cancer (TNBC) research. | ||||||||||||||||||||
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Keywords
