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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
16 Results for "
UCHL5
" in MedChemExpress (MCE) Product Catalog:
Products (16)
16 Results for "UCHL5" in MCE Product Catalog:
13
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Research Areas:
b-AP15 is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14.
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USP28-IN-4 is a USP28 inhibitor (IC50=0.04 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-4 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-4 also decreases the ankyrase-1/2 level in vitro. USP28-IN-4 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .
Cat. No.: HY-RS15402
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UCHL5 Human Pre-designed siRNA Set A contains three designed siRNAs for UCHL5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18192
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Uchl5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Uchl5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS24666
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Uchl5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Uchl5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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USP28-IN-3 is a USP28 inhibitor (IC50=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .
Cat. No.: HY-149228
CAS No.: 2931509-11-2
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USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331) .
Cat. No.: HY-15432
CAS No.: 330450-45-8
Synonyms: (E/Z)-b-AP15
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(E/Z)-NSC-687852 is a isomer of NSC-687852 (HY-13989). NSC687852 (b-AP15) is a specific inhibitor of the deubiquitinating enzymes UCHL5 and Usp14 .
Cat. No.: HY-164689
CAS No.: 18897-36-4
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Cadmium pyrithione is a metal compound that inhibits protein deubiquitinase activity. Cadmium pyrithione treatment results in significant accumulation of ubiquitinated proteins in cancer cells and primary leukemia cells. Cadmium pyrithione strongly inhibits the activity of proteasome deubiquitinase (such as USP14 and UCHL5), but has a smaller inhibitory effect on 20S proteasome activity. The anticancer activity of Cadmium pyrithione is associated with the induction of apoptosis through caspase activation. Furthermore, Cadmium pyrithione inhibition inhibited proteasome function and suppressed tumor growth in animal xenograft models .
Cat. No.: HY-P701406
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UCHL5; Ubiquitin C‑Terminal Hydrolase L5; UCH37; CGI‑70; INO80R; Ubiquitin Carboxyl‑Terminal Hydrolase Isozyme L5; Ubiquitin Carboxyl‑Terminal Hydrolase L5; Ubiquitin C‑Terminal Hydrolase UCH37; Ubiquitin Thioesterase L5; INO80 Complex Subunit R; UCH‑L5;
Cat. No.: HY-D1236
CAS No.: 16090-02-1
Cat. No.: HY-P82598A
Synonyms: UIP1; UCHL5IP
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
