2931509-14-5
Chemical Structure
USP28-IN-3
- CAS No.: 2931509-14-5
- Formula:C23H20Cl2N2O3S
- Molecular Weight:475.39
IUPAC Name: 2-chloro-N-(4-chloro-3-(1,2,3,4-tetrahydroisoquinolin-6-yl)phenyl)-4-(methylsulfonyl)benzamide
InChIKey: CSUMERAOZKVEGF-UHFFFAOYSA-N
SMILES: CS(=O)(C1=CC=C(C(Cl)=C1)C(NC2=CC=C(C(C3=CC4=C(CNCC4)C=C3)=C2)Cl)=O)=O
Biological Activity: USP28-IN-3 is a USP28 inhibitor (IC50=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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USP28-IN-3 | 98.26% | USP28-IN-3 is a USP28 inhibitor (IC50=0.1 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-3 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-3 also decreases the ankyrase-1/2 level in vitro. USP28-IN-3 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331). | ||||||||||||||||||||
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Keywords
