2931509-11-2
Chemical Structure
USP28-IN-2
- CAS No.: 2931509-11-2
- Formula:C23H20Cl2N2O3S
- Molecular Weight:475.39
IUPAC Name: N-(4'-(1-aminocyclopropyl)-6-chloro-[1,1'-biphenyl]-3-yl)-2-chloro-4-(methylsulfonyl)benzamide
InChIKey: MUPIRUJKOJAAJO-UHFFFAOYSA-N
SMILES: CS(=O)(C1=CC=C(C(Cl)=C1)C(NC2=CC=C(C(C3=CC=C(C=C3)C4(CC4)N)=C2)Cl)=O)=O
Biological Activity: USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331)[1].
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USP28-IN-2 | USP28-IN-2 is a USP28 inhibitor (IC50=0.3 μM) with high selectivity over USP2, USP7, USP8, USP9x, UCHL3 and UCHL5. USP28-IN-2 shows cytotoxicity against cancer cells, down-regulates the cellular level of c-Myc through ubiquitin-proteasome system. USP28-IN-2 also decreases the ankyrase-1/2 level in vitro. USP28-IN-2 enhance the sensitivity of colorectal cancer cells to Regorafenib (HY-10331). | |||||||||||||||||||||
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Keywords
