16090-02-1
Chemical Structure
Fluorescent brightener 71
- CAS No.: 16090-02-1
- Formula:C40H38N12Na2O8S2
- Molecular Weight:924.91
IUPAC Name: sodium (E)-6,6'-(ethene-1,2-diyl)bis(3-((4-morpholino-6-(phenylamino)-1,3,5-triazin-2-yl)amino)benzenesulfonate)
InChIKey: VUJGKADZTYCLIL-YHPRVSEPSA-L
SMILES: O=S(C1=CC(NC2=NC(N3CCOCC3)=NC(NC4=CC=CC=C4)=N2)=CC=C1/C=C/C5=CC=C(NC6=NC(N7CCOCC7)=NC(NC8=CC=CC=C8)=N6)C=C5S(=O)(O[Na])=O)(O[Na])=O
Biological Activity: Fluorescent brightener 71 (FB71) is an inhibitor targeting deubiquitinases UCHL5 and USP14, as well as a CD40 ligand. Fluorescent brightener 71 blocks enzymatic activity, induces apoptosis, inhibits cell growth and triggers reactive oxygen species production. Meanwhile, Fluorescent brightener 71 upregulates the expression of oxidative stress-related genes gpx-4 and sod-4, and reversibly increases the protein levels of UCHL5 and USP14 through a feedback response. Fluorescent brightener 71 inhibits the growth, movement and reproductive capacity of Caenorhabditis elegans, and also exhibits concentration-dependent toxic effects. Fluorescent brightener 71 can be applied to scientific research in related fields such as breast cancer[1][2][3].
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Fluorescent brightener 71 | Fluorescent brightener 71 (FB71) is an inhibitor targeting deubiquitinases UCHL5 and USP14, as well as a CD40 ligand. Fluorescent brightener 71 blocks enzymatic activity, induces apoptosis, inhibits cell growth and triggers reactive oxygen species production. Meanwhile, Fluorescent brightener 71 upregulates the expression of oxidative stress-related genes gpx-4 and sod-4, and reversibly increases the protein levels of UCHL5 and USP14 through a feedback response. Fluorescent brightener 71 inhibits the growth, movement and reproductive capacity of Caenorhabditis elegans, and also exhibits concentration-dependent toxic effects. Fluorescent brightener 71 can be applied to scientific research in related fields such as breast cancer. | |||||||||||||||||||||
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Fluorescent brightener 71-d10 sodium | Fluorescent brightener 71-d10 (sodium) (Optical Brightener DMS-d10 (sodium)) is the deuterium labeled Fluorescent brightener 71-d10 (sodium) (HY-W714795). | |||||||||||||||||||||
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References
- [1]. Castro I, et al. Proteasome-associated cysteine deubiquitinases are molecular targets of environmental optical brightener compounds. J Cell Biochem. 2019;120(8):14065-14075. [Content Brief]
- [2]. Castro-Sierra I, et al. Toxicity of Three Optical Brighteners: Potential Pharmacological Targets and Effects on Caenorhabditis elegans. Toxics. 2024 Jan 9;12(1):51. [Content Brief]
- [3]. Chen H, et al. Identification of Fluorescent Brighteners as Another Emerging Class of Abundant, Ubiquitous Pollutants in the Indoor Environment. Environ Sci Technol. 2022;56(14):10131-10140. [Content Brief]
