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VV

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (4) Arenavirus (1) Bacterial (4) Biochemical Assay Reagents (1) DNA Methyltransferase (1) DNA/RNA Synthesis (1) Endogenous Metabolite (3) Environmental Pollutants (1) HSV (1) Influenza Virus (3) Isotope-Labeled Compounds (1) Orthopoxvirus (4) Reference Standards (3) RSV (1) SARS-CoV (3) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (1) Infection (11)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107931

Propiolactone β-propiolactone; 2-Oxetanone; Betaprone	Environmental Pollutants SARS-CoV	Infection
Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL) .

HY-B0125

Ofloxacin 10+ Cited Publications Hoe-280	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection Cancer
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-145119AS

Mindeudesivir hydrobromide VV116; GS-621763-d1 hydrobromide	SARS-CoV RSV Influenza Virus	Infection
Mindeudesivir (JT001; VV116; GS-621763-d₁) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 .

HY-B0502A

Enrofloxacin monohydrochloride 15+ Cited Publications BAY Vp 2674 monohydrochloride; PD160788 monohydrochloride	Bacterial Antibiotic Orthopoxvirus	Infection
Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC₉₀ of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

HY-160957

*Cap A (Acetonitrile/Acetic Anhydride, 80/20 v/v)*	DNA/RNA Synthesis	Others
Cap A (Acetonitrile/Acetic Anhydride, 80/20 v/v) is a capping reagent that can be used in DNA/RNA synthesis .

HY-172918

VV261	Influenza Virus Arenavirus	Infection
VV261 is an orally active prodrug of 4'-fluorouridine. VV261 inhibits viral RNA-dependent RNA polymerase. VV261 exhibits antiviral activity against CCHFV, SFTSV and LCMV. VV261 can be used in research related to viral infections .

HY-Y1890B

Cremophor EL-10	Biochemical Assay Reagents	Others
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn ²⁺, Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses .

HY-B0125R

Ofloxacin (Standard) Hoe-280 (Standard)	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-145119S

Mindeudesivir VV116 free base; GS-621763-d1	Isotope-Labeled Compounds	Others
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119) . GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .

HY-149023

HSV-1/HSV-2-IN-2	HSV	Infection
HSV-1/HSV-2-IN-2 is a HSV-1, HSV-2 and VV inhibitor with EC₅₀ values of 6.8, 8.9 and 8.9 µM, respectively. HSV-1/HSV-2-IN-2 shows antiviral activity .

HY-106685

Selenazofurin CI 935	Influenza Virus	Infection
Selenazofurin is an antiviral compound used against influenza A and influenza B viruses. Selenazofurin shows antiviral activity in cells against Measles, Para-3, Mumps, VV, HSV-2 with the ED₅₀s of 3.7 μg/ml, 1.3 μg/ml, 8.0 μg/ml, 3.4 μg/ml, 4.3 μg/ml .

HY-RS16365

VV Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
VV Human Pre-designed siRNA Set A contains three designed siRNAs for VV gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

VV Human Pre-designed siRNA Set A VV Human Pre-designed siRNA Set A

HY-B0502AR

Enrofloxacin monohydrochloride (Standard) BAY Vp 2674 monohydrochloride (Standard); PD160788 monohydrochloride (Standard)	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus	Infection
Enrofloxacin (monohydrochloride) (Standard) is the analytical standard of Enrofloxacin (monohydrochloride). This product is intended for research and analytical applications. Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

HY-107931R

Propiolactone (Standard) β-propiolactone (Standard); 2-Oxetanone (Standard); Betaprone (Standard)	SARS-CoV Reference Standards	Infection
Propiolactone (Standard) is the analytical standard of Propiolactone. This product is intended for research and analytical applications. Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL) .

HY-148914

S-Tubercidinylhomocysteine	DNA Methyltransferase	Infection
(S)-Tubercidinylhomocysteine (Page 46) is a potent inhibitor of S-adenosylmethionine-dependent methyltransferase. (S)-Tubercidinylhomocysteine can be used for the study of herpesviruses (HSV) and vaccinia (VV).

Cat. No.	Product Name

HY-L127

Anti-Orthopoxvirus Compound Library	37 compounds
Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. The orthopoxvirus genus consists of 12 viruses including variola virus, vaccinia virus (VV), cowpox viruses (CV), monkeypox virus, and camelpox virus. Smallpox has been eradicated worldwide in 1980, but some other orthopoxvirus, such as monkeypox virus, are still threats to human health. There are not many drugs available for orthopoxvirus treatment. The only product currently available for treatment of complications of Orthopoxvirus infection is vaccinia immunoglobulin (VIG). In 2021, brincidofovir was approved by FDA for the treatment of smallpox and tecovirimat was approved by EMA for the treatment of monkeypox in 2022. A few active compounds including interferon and interferon inducers, and a variety of nucleosides or nucleotides have been reported to have activity against orthopoxvirus. MCE carefully prepared a unique collection of 37 compounds reported with the anti- orthopoxvirus activity which can be used for drug screening and other research about orthopoxvirus.

Anti-Orthopoxvirus Compound Library

37 compounds

Orthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae. The orthopoxvirus genus consists of 12 viruses including variola virus, vaccinia virus (VV), cowpox viruses (CV), monkeypox virus, and camelpox virus. Smallpox has been eradicated worldwide in 1980, but some other orthopoxvirus, such as monkeypox virus, are still threats to human health.

There are not many drugs available for orthopoxvirus treatment. The only product currently available for treatment of complications of Orthopoxvirus infection is vaccinia immunoglobulin (VIG). In 2021, brincidofovir was approved by FDA for the treatment of smallpox and tecovirimat was approved by EMA for the treatment of monkeypox in 2022. A few active compounds including interferon and interferon inducers, and a variety of nucleosides or nucleotides have been reported to have activity against orthopoxvirus.

MCE carefully prepared a unique collection of 37 compounds reported with the anti- orthopoxvirus activity which can be used for drug screening and other research about orthopoxvirus.

Cat. No.	Product Name	Type

HY-Y1890B

Cremophor EL-10	Biochemical Assay Reagents
Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn ²⁺, Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses .

Cremophor EL-10

Biochemical Assay Reagents

Cremophor EL-10 is a nonionic polyoxyethylene castor oil surfactant with multiple functions including organic solubilizer, mixed zinc anode corrosion inhibitor and dendrite growth inhibitor. By forming a physical barrier to block electrolyte contact and constructing oriented hydration channels to reduce the desolvation energy barrier of Zn ²⁺, Cremophor EL-10 achieves a corrosion inhibition efficiency of over 99%. Cremophor EL-10 exerts no significant effects on the mitochondrial activity and cell viability of epithelial cells, making it suitable for in vitro drug delivery and biopharmaceutical research at concentrations ≤10% v/v. However, Cremophor EL-10 may induce sustained non-endothelium-dependent contraction in rat aortic rings and exert concentration-dependent inhibitory effects on acetylcholine-induced endothelium-dependent relaxation responses .

Cat. No.	Product Name	Target	Research Area

HY-P5364

B8R 20-27	Peptides	Others
B8R 20-27 is a biological active peptide. (This is amino acids 20 to 27 fragment of B8R, a vaccinia virus (VV) gene that encodes a secreted protein related to gamma interferon receptor. B8R binding to IFN-g neutralizes its antiviral activity.)

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0125

Ofloxacin 10+ Cited Publications Hoe-280	Infection Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification	Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-B0125R

Ofloxacin (Standard) Hoe-280 (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Ofloxacin (Standard) is the analytical standard of Ofloxacin. This product is intended for research and analytical applications. Ofloxacin (Hoe-280) is a fluoroquinolone whose primary mechanism of action is inhibition of bacterial DNA gyrase. Ofloxacin shows inhibitory activity against vaccinia virus (VV).

HY-B0502AR

Enrofloxacin monohydrochloride (Standard) BAY Vp 2674 monohydrochloride (Standard); PD160788 monohydrochloride (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Bacterial Antibiotic Endogenous Metabolite Orthopoxvirus
Enrofloxacin (monohydrochloride) (Standard) is the analytical standard of Enrofloxacin (monohydrochloride). This product is intended for research and analytical applications. Enrofloxacin monohydrochloride (BAY Vp 2674 monohydrochloride) is an effective antibiotic with an MIC90 of 0.312 μg/mL for Mycoplasma bovis. Enrofloxacin monohydrochloride shows inhibitory activity against vaccinia virus (VV).

Cat. No.	Product Name	Chemical Structure

HY-145119AS

Mindeudesivir hydrobromide
Mindeudesivir (JT001; VV116; GS-621763-d₁) hydrobromide is a deuterated version of Remdesivir (HY-104077), a highly orally active nucleoside antiviral against SARS-CoV-2 and respiratory syncytial virus (RSV). Mindeudesivir hydrobromide retains the antiviral activity of Remdesivir against COVID-19, and is the first domestically produced deuterium targeting the COVID-19 .

HY-145119S

Mindeudesivir
GS-621763-d₁ is the deuterium labeled GS-621763 (HY-145119) . GS-621763, an orally bioavailable proagent of GS-441524, shows antiviral activity against SARS-CoV-2 pathogenesis in mice .

VV Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
VV Human Pre-designed siRNA Set A contains three designed siRNAs for VV gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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VV

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products