57-57-8
57-57-8
Chemical Structure
Propiolactone
Synonym(s): β-propiolactone; 2-Oxetanone; Betaprone
- CAS No.: 57-57-8
- Formula:C3H4O2
- Molecular Weight:72.06
IUPAC Name: oxetan-2-one
InChIKey: VEZXCJBBBCKRPI-UHFFFAOYSA-N
SMILES: O=C1OCC1
Biological Activity: Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Propiolactone | 99.97% | Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Propiolactone (Standard) | ≥98% | Propiolactone (Standard) is the analytical standard of Propiolactone. This product is intended for research and analytical applications. Propiolactone (β-propiolactone; 2-Oxetanone) is a viral chemical inactivator that causes the infectious inactivation of viruses. Propiolactone was co-incubated with SARS-CoV at a ratio of 1:1000 (v:v) and used as a bacteriostatic agent to formulate the BPL-inactivated influenza virus vaccine (Flu-BPL). | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.84
HY-W012997Tetrahydro-2H-pyran-2-one -
Similarity Score 0.80
HY-W015891Rε-Caprolactone (Standard) -
Similarity Score 0.75
HY-79369RSuccinic anhydride (Standard) -
Similarity Score 0.75
HY-79369S1Succinic anhydride-13C2 -
Similarity Score 0.74
HY-764403-Oxetanone -
Similarity Score 0.66
HY-N154171,13-Tridecanolide -
Similarity Score 0.64
HY-Z0059Sacubitrilat impurity 32 -
Similarity Score 0.60
HY-W5859424-Methylhexahydroisobenzofuran-1,3-dione -
Similarity Score 0.59
HY-W094155Methyl (1S)-3-oxocyclopentaneacetate -
Explore the MedChemAI to find more analogs
References
- [1]. Roberts A, et al. Immunogenicity and protective efficacy in mice and hamsters of a β-propiolactone inactivated whole virus SARS-CoV vaccine. Viral Immunol. 2010 Oct;23(5):509-19 [Content Brief]
- [2]. Kulkarni R, et al. Anti-SARS-CoV-2 IgG antibody response among Indian COVID-19 patients using β-propiolactone-inactivated, whole virus-based indirect ELISA. J Virol Methods. 2021 Jan;287:113996. [Content Brief]
