1 Result for "

Xirestomig

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Xirestomig" in MCE Product Catalog:

Xirestomig
Xirestomig
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Cat. No.: HY-P990778
CAS No.: 2756879-35-1
Synonyms: ATG-101

Target:  

TNF Receptor PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Xirestomig (ATG-101) is a tetravalent "2+2″ PD-L1×4-1BB bispecific antibody. Xirestomig binds PD-L1 and 4-1BB concurrently, with a greater affinity for PD-L1, and potently activated 4-1BB+ T cells when cross-linked with PD-L1-positive cells. Xirestomig activates exhausted T cells upon PD-L1 binding. Xirestomig displays potent antitumor activity in numerous in vivo tumor models, including those resistant or refractory to immune checkpoint inhibitors (ICIs) .
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